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用于抗菌表面应用的硫代甘油三酯复合材料的静态和动态评估

Static and Dynamic Assessments of a Sulfur-Triglyceride Composite for Antimicrobial Surface Applications.

作者信息

Wijeyatunga Shalini K, Sauceda-Oloño Perla Y, Kapuge Dona Nawoda L, Guinati Bárbara G S, Derr Katelyn M, Tisdale Katelyn A, Smith Ashlyn D, Tennyson Andrew G, Smith Rhett C

机构信息

Department of Chemistry, Clemson University, Clemson, SC 29634, USA.

Department of Materials Science and Engineering, Clemson University, Clemson, SC 29634, USA.

出版信息

Molecules. 2025 Apr 4;30(7):1614. doi: 10.3390/molecules30071614.

Abstract

Over 80 MT of elemental sulfur, a byproduct of fossil fuel desulfurization, are generated annually. This has spurred the development of high sulfur content materials (HSMs) via inverse vulcanization as a productive pathway towards sulfur utilization. In this study, we evaluate the antimicrobial performance of SunBG, an HSM made from brown grease and sulfur, as tiles or infused into fabric squares. The static antimicrobial activity of SunBG tiles was assessed, revealing excellent efficacy against Gram-positive bacteria, with reductions of 96.84% for and 91.52% for . The tiles also exhibited strong antifungal activity, reducing by 96.20% and mold () by 83.77%. In contrast, efficacy against Gram-negative bacteria was more variable, with moderate reductions for (61.10%) and (62.15%), lower activity against and , and no effect on . Under dynamic conditions, SunBG-infused fabrics achieved a near-complete inhibition of (99.91%) and high reduction of (98.49%), along with a 96.24% inhibition of . These results highlight the potential and limitations of SunBG for antimicrobial applications, emphasizing the need for further optimization to achieve consistent broad-spectrum activity.

摘要

每年会产生超过80公吨的元素硫,这是化石燃料脱硫的一种副产品。这促使人们通过逆硫化反应开发高硫含量材料(HSMs),将其作为一种利用硫的有效途径。在本研究中,我们评估了SunBG(一种由棕色油脂和硫制成的高硫含量材料)作为瓷砖或注入织物方块后的抗菌性能。评估了SunBG瓷砖的静态抗菌活性,结果显示其对革兰氏阳性菌具有优异的抗菌效果,对金黄色葡萄球菌的抑菌率为96.84%,对表皮葡萄球菌的抑菌率为91.52%。这些瓷砖还表现出很强的抗真菌活性,对白色念珠菌的抑菌率为96.20%,对霉菌(黑曲霉)的抑菌率为83.77%。相比之下,其对革兰氏阴性菌的抗菌效果则更不稳定,对大肠杆菌的抑菌率为中等水平(61.10%),对铜绿假单胞菌的抑菌率为62.15%,对肺炎克雷伯菌和鲍曼不动杆菌的活性较低,对嗜麦芽窄食单胞菌则没有效果。在动态条件下,注入SunBG的织物对金黄色葡萄球菌实现了近乎完全的抑制(99.91%),对大肠杆菌有较高的抑菌率(98.49%),对白色念珠菌的抑菌率为96.24%。这些结果突出了SunBG在抗菌应用中的潜力和局限性,强调了进一步优化以实现一致的广谱活性的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78b/11990873/2e526b787a66/molecules-30-01614-g001.jpg

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