Yuan Yun, Li Zirong, Wu Leilei, Cheng Xinyi, Deng Chao, Yu Yuanyuan, Wang Qiang, Wang Ping
Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, Jiangnan University, Wuxi, 214122, People's Republic of China.
Wuxi Medical School, Jiangnan University, Wuxi, 214122, People's Republic of China.
Biomaterials. 2025 Nov;322:123360. doi: 10.1016/j.biomaterials.2025.123360. Epub 2025 Apr 23.
The treatment of chronic wounds remains a significant challenge in the clinical field, and optimizing the treatment plan through visual monitoring of wound healing is an effective way to solve such problem. Herein, we propose a feasible strategy to construct a smearable C-P-T/mCQDs hydrogel for real-time monitoring of wound infection and healing status, through the synergistic combination of modified carbon quantum dots (mCQD), cellulose nanofiber, tannic acid, and polyvinyl alcohol. The hydrogel can be readily applied on the skin and rapidly forms a gel dressing through high-density hydrogen bonding, demonstrating exceptional mechanical robustness (tensile elongation: 600 %) and autonomous self-healing capabilities. In particular, the carboxyl-rich mCQDs are more easily recognized by the sensitive pH-mediated polychromatic fluorescence response under ultraviolet excitation, exhibiting encouraging photodynamic therapy effect against bacterial infections. Under the irradiation of sunlight or near-infrared laser, the hydrogel achieves 99.99 % bactericidal efficacy against multiple types of bacteria (S. aureus, E. coli, P. aeruginosa, A. baumannii) within 20 min through reactive oxygen species generation. Furthermore, C-P-T/mCQDs demonstrates excellent antioxidant activity, biocompatibility, hemostatic efficiency and pro-healing properties. Notably, the mCQD-integrated hydrogel enables real-time, visual monitoring of wound status through its pH-responsive properties, providing substantial translational potential for personalized chronic wound management.
慢性伤口的治疗仍是临床领域的一项重大挑战，通过对伤口愈合进行视觉监测来优化治疗方案是解决这一问题的有效途径。在此，我们提出了一种可行的策略，通过修饰碳量子点（mCQD）、纤维素纳米纤维、单宁酸和聚乙烯醇的协同组合，构建一种可涂抹的C-P-T/mCQDs水凝胶，用于实时监测伤口感染和愈合状态。该水凝胶可轻松涂抹于皮肤上，并通过高密度氢键迅速形成凝胶敷料，具有出色的机械强度（拉伸伸长率：600%）和自主自愈能力。特别是，富含羧基的mCQDs在紫外光激发下更容易被敏感的pH介导的多色荧光响应识别，对细菌感染表现出令人鼓舞的光动力治疗效果。在阳光或近红外激光照射下，该水凝胶通过产生活性氧在20分钟内对多种细菌（金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌、鲍曼不动杆菌）实现99.99%的杀菌效果。此外，C-P-T/mCQDs表现出优异的抗氧化活性、生物相容性、止血效率和促愈合特性。值得注意的是，集成mCQD的水凝胶通过其pH响应特性能够实时、可视化地监测伤口状态，为个性化慢性伤口管理提供了巨大的转化潜力。
