Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.
Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Int J Biol Macromol. 2023 May 31;238:124123. doi: 10.1016/j.ijbiomac.2023.124123. Epub 2023 Mar 22.
Recurrent infection of chronic wounds remains a major clinical challenge. Recently, the hydrogel antibacterial materials have attracted extensive attention for preventing infection in wound healing. In this study, a hybrid hydrogel made of polyvinyl alcohol - iodine (PAI), sodium carboxymethyl cellulose (CMC), and carbamino quantum dot (CQDs) was prepared by the cross-linking of hydrogen bonds, named as polyvinyl alcohol‑iodine/sodium carboxymethyl cellulose/carbon quantum dots (PAI/CMC/CQDs). The composite hydrogels exhibited the outstanding photothermal conversion efficiency with near infrared (NIR) light irradiation, and the high antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Meanwhile, the elevated temperature of the composite hydrogels up to ∼45 °C was able to stimulate the migration of epidermal cell to accelerate skin repair. Given that PAI and CQDs could respond to different pH values (5-8), the real-time would pH information was provided by the visible light and fluorescent light dual monitoring system by naked eye. Moreover, the visible-fluorescent images could be collected and transformed into RGB signals to quantify the would pH levels, avoiding secondary injuries caused by frequent dressing changes. PAI/CMC/CQDs was demonstrated the significant therapeutic effect on chronic wounds by eliminating bacterial infections and promoting skin repair under the smart RGB monitoring system.
慢性伤口的反复感染仍然是一个主要的临床挑战。最近，水凝胶抗菌材料因其在伤口愈合中预防感染的作用而受到广泛关注。在这项研究中，通过氢键交联制备了一种由聚乙烯醇-碘（PAI）、羧甲基纤维素钠（CMC）和碳量子点（CQDs）组成的杂化水凝胶，命名为聚乙烯醇-碘/羧甲基纤维素/碳量子点（PAI/CMC/CQDs）复合水凝胶。该复合水凝胶在近红外（NIR）光照射下表现出优异的光热转换效率和对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）的高抗菌活性。同时，复合水凝胶的温度升高到约 45°C 能够刺激表皮细胞迁移，从而加速皮肤修复。鉴于 PAI 和 CQDs 可以响应不同的 pH 值（5-8），通过肉眼可见的光和荧光双重监测系统提供实时 pH 值信息。此外，可以收集可见-荧光图像并将其转换为 RGB 信号来定量伤口的 pH 值水平，避免因频繁更换敷料而造成的二次损伤。在智能 RGB 监测系统下，PAI/CMC/CQDs 消除了细菌感染并促进了皮肤修复，从而对慢性伤口表现出显著的治疗效果。
