Saidi Nurain Izzati, Azhar Nur Athirah, Jahaya Mohamad Azlan, Shamsuddin Mohd Shafarin, Zamzuri Syahrol
Central Zone Veterinary Laboratory, Malaysia Department of Veterinary Services, Sepang, Selangor, Malaysia.
Central Zone Veterinary Laboratory, Malaysia Department of Veterinary Services, Sepang, Selangor, Malaysia.
Vet J. 2025 Aug;312:106365. doi: 10.1016/j.tvjl.2025.106365. Epub 2025 Apr 24.
Lumpy skin disease is a transboundary viral disease affecting bovine species. This disease had never been recorded in Malaysia prior to May of 2021, and had spread to 65 of 92 districts in Peninsular Malaysia by December of the same year. In this study, we conducted a whole-genome sequencing, phylogenetic analysis and geographical mapping of the outbreak from lumpy skin disease virus isolated from the first wave of outbreaks to better understand the origin, transmission, and genetic diversity of the virus. The whole genome sequences of these isolates were deposited in GenBank with accession number PP145891 and PP145892. Malaysia LSDV isolates were found clustered with recombinant strains in clade 2.5, particularly subclade 2.5.1, which included strains from China, Vietnam, Thailand, and Indonesia. The spread of the disease in Malaysia was closely linked to cross-border cattle movements from Thailand, as evidenced by the spatiotemporal distribution of the outbreaks. This study emphasizes the need for ongoing genomic surveillance to detect emerging variants and inform targeted control strategies, including vaccination and cross-border cooperation to curb future outbreaks.
结节性皮肤病是一种影响牛类的跨界病毒性疾病。在2021年5月之前，马来西亚从未记录过这种疾病，到同年12月，它已蔓延至马来西亚半岛92个区中的65个区。在本研究中，我们对从第一波疫情中分离出的结节性皮肤病病毒疫情进行了全基因组测序、系统发育分析和地理绘图，以更好地了解该病毒的起源、传播和遗传多样性。这些分离株的全基因组序列已存入GenBank，登录号为PP145891和PP145892。发现马来西亚结节性皮肤病病毒分离株与2.5进化枝中的重组菌株聚集在一起，特别是2.5.1亚进化枝，其中包括来自中国、越南、泰国和印度尼西亚的菌株。疫情在马来西亚的传播与来自泰国的跨境牛只流动密切相关，疫情的时空分布证明了这一点。本研究强调需要持续进行基因组监测，以检测新出现的变异株，并为有针对性的控制策略提供信息，包括疫苗接种和跨境合作，以遏制未来的疫情。
