RNA修饰：假尿苷（Ψ）及其在植物功能生物学中的作用的当代综述

RNA modification: A contemporary review of pseudouridine (Ψ) and its role in functional plant biology.

作者信息

Khan Ahsan, Anicet Gatera, Asdullah Hafiz Umair, Hassan Muhammad Ahmad, Song Youhong

机构信息

School of Agronomy, Anhui Agricultural University, Hefei 230036, Anhui Province, China.

College of Resource and Environment, Anhui Agricultural University, Hefei 230036, China.

出版信息

Plant Sci. 2025 Jul;356:112522. doi: 10.1016/j.plantsci.2025.112522. Epub 2025 Apr 24.

DOI:10.1016/j.plantsci.2025.112522

PMID:40287098

Abstract

Pseudouridine (Ψ) is a modified nucleoside present in diverse RNA species, including mRNA (messenger RNA), snRNA (small nuclear RNA), rRNA (ribosomal RNA) and tRNA (transfer RNA). In plants, Ψ serves a critical function in RNA modification, supporting the stability, structural integrity, and functionality of RNA molecules. This review provides the various roles that Ψ fulfils in the modification of plant RNA biology, encompassing effects on biosynthesis pathways, regulatory mechanisms, stability, and translation efficiency. Additionally, we discuss recent advancements in the dynamic regulation of Ψ deposition in response to environmental stimuli and stressors. Elucidating Ψ's roles contributes to the comprehension of plant biology and may facilitate developments in biotechnology and crop improvement.

摘要

假尿苷（Ψ）是一种存在于多种RNA种类中的修饰核苷，包括信使RNA（mRNA）、小核RNA（snRNA）、核糖体RNA（rRNA）和转运RNA（tRNA）。在植物中，Ψ在RNA修饰中发挥关键作用，支持RNA分子的稳定性、结构完整性和功能。本综述阐述了Ψ在植物RNA生物学修饰中所起的各种作用，包括对生物合成途径、调控机制、稳定性和翻译效率的影响。此外，我们还讨论了在响应环境刺激和应激源时，Ψ沉积动态调控方面的最新进展。阐明Ψ的作用有助于理解植物生物学，并可能促进生物技术和作物改良的发展。