Lee Jingu, Jin Bo-Ram, Cho Jaehyung
Division of Hematology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, United States.
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, United States.
Hum Mol Genet. 2025 Apr 27. doi: 10.1093/hmg/ddaf008.
Neutrophils are the most abundant leukocytes in humans and are indispensable for innate immunity. They are short-lived, terminally differentiated cells. However, mounting evidence indicates that neutrophils are heterogeneous in health and disease: they are young or aged in a steady state, while their heterogeneity becomes more diverse in disease conditions, such as cancer, sepsis, and thromboinflammation. Although the presence of distinct neutrophil subsets is well recognized, it is not fully understood how neutrophils have functional and phenotypic heterogeneity and what mechanisms control it. This review will focus on our current understanding of the molecular basis for neutrophil heterogeneity in pathophysiological conditions. In addition, we will discuss the possibility of targeting a specific subset of neutrophils to attenuate inflammation and tissue damage without compromising innate immune responses.
中性粒细胞是人类体内数量最多的白细胞，对固有免疫不可或缺。它们是寿命短暂、终末分化的细胞。然而，越来越多的证据表明，中性粒细胞在健康和疾病状态下具有异质性：在稳态时它们有年轻或衰老之分，而在疾病状态如癌症、脓毒症和血栓炎症中，其异质性变得更加多样。尽管不同中性粒细胞亚群的存在已得到充分认识，但中性粒细胞如何具有功能和表型异质性以及何种机制对其进行调控，目前尚未完全明确。本综述将聚焦于我们目前对病理生理条件下中性粒细胞异质性分子基础的理解。此外，我们还将探讨靶向特定中性粒细胞亚群以减轻炎症和组织损伤同时又不损害固有免疫反应的可能性。
