Li Yanlin, Tang Jingjing, Tang Wei, Liu Cong, Li Zhenkui
Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Department of Health Inspection and Quarantine, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Acta Trop. 2025 Jun;266:107634. doi: 10.1016/j.actatropica.2025.107634. Epub 2025 Apr 25.
Malaria, a severe parasitic disease caused by Plasmodium infections, remains a major global health challenge. Efforts to eradicate malaria are complicated by the parasite's intricate life cycle, which alternates between vertebrate hosts and mosquito vectors. Host-derived factors and parasite-sourced components exert crucial roles in regulating this biological process. This review explores the critical role of host-derived factors in shaping Plasmodium sexual differentiation and transmission. We examine how vertebrate and mosquito host-specific factors either promote or restrict parasite development, influencing the transition from vertebrates to mosquitoes. Understanding these host-mediated mechanisms is crucial for developing novel transmission-blocking strategies to reduce malaria prevalence. By highlighting key interactions between hosts and parasites, this review provides insights into potential interventions that could disrupt Plasmodium transmission and contribute to malaria control efforts.
疟疾是一种由疟原虫感染引起的严重寄生虫病，仍然是全球主要的健康挑战。疟原虫复杂的生命周期在脊椎动物宿主和蚊子媒介之间交替，这使得根除疟疾的努力变得复杂。宿主衍生因子和寄生虫来源的成分在调节这一生物学过程中发挥着关键作用。本综述探讨了宿主衍生因子在塑造疟原虫性别分化和传播中的关键作用。我们研究了脊椎动物和蚊子宿主特异性因子如何促进或限制寄生虫的发育，影响从脊椎动物到蚊子的转变。了解这些宿主介导的机制对于开发新的传播阻断策略以降低疟疾流行率至关重要。通过强调宿主与寄生虫之间的关键相互作用，本综述提供了对可能破坏疟原虫传播并有助于疟疾控制努力的潜在干预措施的见解。
