Zhang Ran, Liu Xueyao, Zhang Wenli, Cui Benke, Du Yongduo, Huang Yanan, Li Wenjun, Liu Qun, Ren Chunguang, Tang Zhihong
School of Life Sciences, Yantai University, Yantai 264005, Shandong, China.
School of Pharmacy, Yantai University, Yantai 264005, Shandong, China.
Int J Biol Macromol. 2025 May;310(Pt 4):143519. doi: 10.1016/j.ijbiomac.2025.143519. Epub 2025 Apr 25.
Hydrogels prepared from natural polysaccharide possess excellent biocompatibility and adjustable physical properties similar to those of natural extracellular matrices, and have thus been extensively utilized in the biomedical field. However, natural polysaccharide hydrogels have limited applications owing to their performance deficiencies. For instance, poor mechanical properties restrict their application in tissue engineering, while instability hinders their adaptation to complex and dynamic physiological environments. The chemical modification of polysaccharides and their combination with other matrix materials, such as proteins, synthetic polymers, and inorganic materials, to form hybrid hydrogels have been utilized to enhance the properties of polysaccharide-based hydrogels for diverse applications. This paper reviews comprehensively and systematically the methods of natural polysaccharide modification and describes in detail the various types of polysaccharide-based hydrogels. Additionally, the applications of these hydrogels in drug delivery, wound dressings, tissue engineering and biosensing are summarized. Finally, the challenges and future directions for the application of polysaccharide-based hydrogels are envisioned to provide a reference for the design of novel multifunctional hydrogels.
由天然多糖制备的水凝胶具有优异的生物相容性和与天然细胞外基质相似的可调节物理性质，因此已在生物医学领域得到广泛应用。然而，天然多糖水凝胶由于其性能缺陷而应用有限。例如，较差的机械性能限制了它们在组织工程中的应用，而不稳定性阻碍了它们适应复杂和动态的生理环境。多糖的化学修饰及其与其他基质材料（如蛋白质、合成聚合物和无机材料）结合形成杂化水凝胶，已被用于增强基于多糖的水凝胶的性能以用于各种应用。本文全面系统地综述了天然多糖的修饰方法，并详细描述了各种类型的基于多糖的水凝胶。此外，总结了这些水凝胶在药物递送、伤口敷料、组织工程和生物传感中的应用。最后，展望了基于多糖的水凝胶应用面临的挑战和未来方向，为新型多功能水凝胶的设计提供参考。
