Liu Xiaoxi, Yu Hongli, Gou Fushuai, Du Boai, Lu Pengyi, Wang Chunfang
School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2025 Apr 25;42(2):280-287. doi: 10.7507/1001-5515.202411054.
Transcranial temporal interference stimulation (tTIS) is a novel non-invasive transcranial electrical stimulation technique that achieves deep brain stimulation through multiple electrodes applying electric fields of different frequencies. Current studies on the mechanism of tTIS effects are primarily based on rodents, but experimental outcomes are often significantly influenced by electrode configurations. To enhance the performance of tTIS within the limited cranial space of rodents, we proposed various electrode configurations for tTIS and conducted finite element simulations using a realistic mouse model. Results demonstrated that ventral-dorsal, four-channel bipolar, and two-channel configurations performed best in terms of focality, diffusion of activated brain regions, and scalp impact, respectively. Compared to traditional transcranial direct current stimulation (tDCS), these configurations improved by 94.83%, 50.59%, and 3 514.58% in the respective evaluation metrics. This study provides a reference for selecting electrode configurations in future tTIS research on rodents.
经颅颞叶干扰刺激（tTIS）是一种新型非侵入性经颅电刺激技术，通过多个电极施加不同频率的电场来实现深部脑刺激。目前关于tTIS效应机制的研究主要基于啮齿动物，但实验结果常受电极配置的显著影响。为了在啮齿动物有限的颅腔内提高tTIS的性能，我们提出了用于tTIS的各种电极配置，并使用真实的小鼠模型进行了有限元模拟。结果表明，腹背、四通道双极和双通道配置分别在聚焦性、激活脑区扩散和头皮影响方面表现最佳。与传统经颅直流电刺激（tDCS）相比，这些配置在各自的评估指标上分别提高了94.83%、50.59%和3514.58%。本研究为未来啮齿动物tTIS研究中电极配置的选择提供了参考。
