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本文引用的文献

1
Zinc-doped bioactive glass-functionalized polyetheretherketone to enhance the biological response in bone regeneration.锌掺杂生物活性玻璃功能化聚醚醚酮以增强骨再生中的生物学反应。
J Biomed Mater Res A. 2024 Sep;112(9):1565-1577. doi: 10.1002/jbm.a.37710. Epub 2024 Mar 21.
2
Improving dental implant stability by optimizing thread design: Simultaneous application of finite element method and data mining approach.通过优化螺纹设计提高牙种植体稳定性:有限元法与数据挖掘方法的同步应用
J Prosthet Dent. 2023 Oct;130(4):602.e1-602.e11. doi: 10.1016/j.prosdent.2023.06.034. Epub 2023 Aug 1.
3
Coating of manganese functional polyetheretherketone implants for osseous interface integration.用于骨界面整合的锰功能化聚醚醚酮植入物涂层
Front Bioeng Biotechnol. 2023 May 3;11:1182187. doi: 10.3389/fbioe.2023.1182187. eCollection 2023.
4
Bio-Activated PEEK: Promising Platforms for Improving Osteogenesis through Modulating Macrophage Polarization.生物活性聚醚醚酮:通过调节巨噬细胞极化改善骨生成的有前景的平台。
Bioengineering (Basel). 2022 Dec 1;9(12):747. doi: 10.3390/bioengineering9120747.
5
Clinical Applications of Polyetheretherketone in Removable Dental Prostheses: Accuracy, Characteristics, and Performance.聚醚醚酮在可摘义齿中的临床应用:准确性、特性及性能
Polymers (Basel). 2022 Oct 31;14(21):4615. doi: 10.3390/polym14214615.
6
Magnesium surface-activated 3D printed porous PEEK scaffolds for osseointegration by promoting angiogenesis and osteogenesis.镁表面活化的3D打印多孔聚醚醚酮支架通过促进血管生成和骨生成实现骨整合。
Bioact Mater. 2022 May 18;20:16-28. doi: 10.1016/j.bioactmat.2022.05.011. eCollection 2023 Feb.
7
Modification of polyetheretherketone (PEEK) physical features to improve osteointegration.聚醚醚酮(PEEK)物理性能的改性以提高骨整合性。
J Zhejiang Univ Sci B. 2022 Mar 15;23(3):189-203. doi: 10.1631/jzus.B2100622.
8
Bio-tribological behavior of articular cartilage based on biological morphology.基于生物形态的关节软骨的生物摩擦学行为。
J Mater Sci Mater Med. 2021 Oct 22;32(11):132. doi: 10.1007/s10856-021-06566-y.
9
Enhanced osteogenic activity and antibacterial performance of polyetheretherketone by plasma-induced graft polymerization of acrylic acid and incorporation of zinc ions.通过丙烯酸的等离子体诱导接枝聚合和锌离子的掺入增强聚醚醚酮的成骨活性和抗菌性能。
J Mater Chem B. 2021 Sep 22;9(36):7506-7515. doi: 10.1039/d1tb01349a.
10
The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation.牙种植体表面改性对骨结合和生物膜形成的影响。
J Clin Med. 2021 Apr 12;10(8):1641. doi: 10.3390/jcm10081641.

[通过多种改性方法增强聚醚醚酮植入物骨整合性能的研究进展]

[Research progress on enhancing osseointegration properties of polyetheretherketone implants through various modification methods].

作者信息

Liu Shilai, Feng Xiaoke, Chen Chunxia

机构信息

Department of Prosthodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, P. R. China.

Tianjin Key Laboratory of Oral and maxillofacial Function Reconstruction, Tianjin 300041, P. R. China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2025 Apr 25;42(2):417-422. doi: 10.7507/1001-5515.202408033.

DOI:10.7507/1001-5515.202408033
PMID:40288987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12035625/
Abstract

This review article summarizes the current modification methods employed to enhance the osseointegration properties of polyetheretherketone (PEEK), a novel biomaterial. Our analysis highlights that strategies such as surface treatment, surface modification, and the incorporation of bioactive composites can markedly improve the bioactivity of PEEK surfaces, thus facilitating their effective integration with bone tissue. However, to ensure widespread application of PEEK in the medical field, particularly in oral implantology, additional experiments and long-term clinical evaluations are required. Looking ahead, future research should concentrate on developing innovative modification techniques and assessment methodologies to further optimize the performance of PEEK implant materials. The ultimate goal is to provide the clinical setting with even more reliable solutions.

摘要

这篇综述文章总结了目前用于增强新型生物材料聚醚醚酮(PEEK)骨整合性能的改性方法。我们的分析强调,诸如表面处理、表面改性以及生物活性复合材料的掺入等策略能够显著提高PEEK表面的生物活性,从而促进其与骨组织的有效整合。然而,为确保PEEK在医学领域,尤其是口腔种植学中的广泛应用,还需要进行更多实验和长期临床评估。展望未来,未来的研究应集中于开发创新的改性技术和评估方法,以进一步优化PEEK植入材料的性能。最终目标是为临床提供更可靠的解决方案。