Machado Richard Simon, Mathias Khiany, Joaquim Larissa, da Costa Maiara de Aguiar, Tiscoski Anita, Gonçalves Cinara Ludvig, Rezin Gislaine Tezza, Petronilho Fabricia
Laboratory of Experimental Neurology, Health Sciences Unit, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciuma, Santa Catarina, Brazil.
Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Health Sciences Unit, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, Santa Catarina, Brazil.
Mol Neurobiol. 2025 Apr 28. doi: 10.1007/s12035-025-04983-6.
This review highlights the emerging relevance of meningeal lymphatic vessels (MLVs) in the context of ischemic stroke, challenging the conventional view of a privileged immunological central nervous system. MLVs facilitate immunological surveillance by modulating the entry of peripheral immune cells into the meningeal compartment, a process not impeded by the blood-brain barrier. In ischemic stroke, these vessels play a crucial role in the neuroinflammatory cascade, contributing to immune responses by draining antigens and signals to cervical lymph nodes. Their involvement extends to potential contributions to resolving ischemia-induced cerebral edema, impacting fluid homeostasis. The dynamic interaction among MLVs, neuroinflammation, and fluid dynamics suggests promising therapeutic approaches. Targeting these vessels for immunomodulation, fluid drainage, and preserving blood-brain barrier integrity emerges as an innovative approach to improve ischemic stroke outcomes. However, successful clinical translation awaits further exploration of the therapeutic potential of these vessels. The multifaceted contributions of MLVs provide a compelling rationale for ongoing research, aiming to fully harness their therapeutic impact in ischemic stroke management.
这篇综述强调了脑膜淋巴管（MLVs）在缺血性中风背景下新出现的相关性，挑战了传统的免疫特权中枢神经系统观点。MLVs通过调节外周免疫细胞进入脑膜腔室来促进免疫监视，这一过程不受血脑屏障的阻碍。在缺血性中风中，这些血管在神经炎症级联反应中起关键作用，通过将抗原和信号引流到颈部淋巴结来促进免疫反应。它们的作用还扩展到对解决缺血性脑水肿的潜在贡献，影响液体稳态。MLVs、神经炎症和流体动力学之间的动态相互作用提示了有前景的治疗方法。针对这些血管进行免疫调节、液体引流以及维持血脑屏障完整性，成为改善缺血性中风预后的一种创新方法。然而，要成功实现临床转化，还需进一步探索这些血管的治疗潜力。MLVs的多方面贡献为正在进行的研究提供了令人信服的理论依据，旨在充分利用它们在缺血性中风管理中的治疗作用。
