van Staden Quintin Andre, Muriel Sarah Meiring, Charmaine Conradie, Jaco Joubert
Department of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Department of Haematology and Cell Biology, Universitas Academic Laboratories, National Health Laboratory Service, Bloemfontein, South Africa.
Sci Rep. 2025 Apr 27;15(1):14708. doi: 10.1038/s41598-025-94503-2.
Non-human primates are useful models of human haemostasis, but distinctions do exist. These differences are essential to identify and quantify to better characterise the Chacma baboon's coagulation system. The Chacma baboon's factor VIII and natural anticoagulants were characterised and compared to human reference ranges. Parameters were measured using commercial chromogenic and clot-based assays, in 40 Rhesus negative, ABO typed, male and female Chacma baboon platelet poor plasma samples. Free protein S concentration, protein C, protein S and factor VIII activity reference intervals revealed important differences, while antithrombin was similar to humans. Between sexes, reference intervals largely overlapped but were wider for free protein S and protein S activity. Factor VIII activity was 14% lower in group O baboons. This research has quantified some of the coagulation similarities and differences between Chacma baboons and humans.
非人灵长类动物是人类止血的有用模型，但差异确实存在。识别和量化这些差异对于更好地描述东非狒狒的凝血系统至关重要。对东非狒狒的凝血因子VIII和天然抗凝剂进行了表征，并与人类参考范围进行了比较。使用商业显色法和基于凝血块的检测方法，对40份恒河猴阴性、ABO血型、雌雄东非狒狒的乏血小板血浆样本进行了参数测量。游离蛋白S浓度、蛋白C、蛋白S和凝血因子VIII活性参考区间显示出重要差异，而抗凝血酶与人类相似。在性别之间，参考区间大部分重叠，但游离蛋白S和蛋白S活性的参考区间更宽。O型狒狒的凝血因子VIII活性低14%。这项研究已经量化了东非狒狒和人类之间凝血的一些异同。
