Ibars-Serra Maria, Pascual-Serrano Aïda, Ardid-Ruiz Andrea, Doladé Núria, Aguilar-González Sonia, Cirasino Julieta, Muguerza Begoña, Suárez Manuel, Keijer Jaap, Arola-Arnal Anna, Aragonès Gerard
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain.
Human and Animal Physiology, Wageningen University, Wageningen, the Netherlands.
Mol Nutr Food Res. 2025 Aug;69(15):e70075. doi: 10.1002/mnfr.70075. Epub 2025 Apr 27.
In obesity, increased adipocyte size is associated with metabolic complications, while elevated adipocyte numbers are considered a protective mechanism against metabolic disturbances. Adipose tissue dysfunction leads to decreased leptin sensitivity and disrupted energy balance regulation. Resveratrol (RSV), a bioactive compound known for potential health benefits, including obesity-related disorder prevention, has unclear modulatory effects on adipocyte dysfunction and leptin signaling in established obesity. This study investigated the impact of RSV on adiposity and hypothalamic leptin sensitivity in obesity. Rats were fed a cafeteria diet for 9 weeks and subsequently supplemented with different doses of RSV for 22 days. The 200 mg/kg RSV dose reduced leptin concentrations, body weight gain, and body fat mass in obese animals, while mitigating adipocyte hypertrophy and promoting adipocyte hyperplasia in the retroperitoneal fat depot. RSV also improved hypothalamic leptin sensitivity, shedding light on the molecular mechanisms underlying the benefits of RSV consumption for obesity-related disorders.
在肥胖症中，脂肪细胞体积增大与代谢并发症相关，而脂肪细胞数量增加被认为是一种针对代谢紊乱的保护机制。脂肪组织功能障碍会导致瘦素敏感性降低和能量平衡调节紊乱。白藜芦醇（RSV）是一种具有潜在健康益处（包括预防肥胖相关疾病）的生物活性化合物，其对已患肥胖症的脂肪细胞功能障碍和瘦素信号传导的调节作用尚不清楚。本研究调查了RSV对肥胖症中肥胖程度和下丘脑瘦素敏感性的影响。大鼠喂食自助餐饮食9周，随后补充不同剂量的RSV，持续22天。200mg/kg的RSV剂量降低了肥胖动物的瘦素浓度、体重增加和体脂量，同时减轻了脂肪细胞肥大，并促进了腹膜后脂肪库中的脂肪细胞增生。RSV还改善了下丘脑瘦素敏感性，揭示了食用RSV对肥胖相关疾病有益的潜在分子机制。
