Mild Phototherapy Strategies for Preventing Pathogen Infection and Enhancing Cell Proliferation in Diabetic Wound.

Excessive inflammation, bacterial infection, and impaired cell proliferation posed significant challenges to diabetic wound healing. There is an urgent need for an effective method that can simultaneously provide antibacterial activity and promote cell proliferation to facilitate the healing of bacteria-infected diabetic wounds. In this study, a novel nanoplatform, GDYO-VPIM-Au is designed, by co-decorating 1-vinyl-3-pentylimidazolium bromide ([VPIM]Br) and gold nanorods (Au NRs) on graphdiyne oxide (GDYO) nanosheets. GDYO-VPIM-Au exhibited excellent antibacterial properties against drug-resistant bacteria through reactive oxygen species (ROS) generation and electrostatic interactions. Moreover, GDYO-VPIM-Au with the synergistic effect of mild phototherapy therapy (mPTT) produced by Au NRs can promote efficient cell proliferation and significantly accelerate the healing of infected diabetic wounds. This work represented a promising therapeutic strategy for addressing drug-resistant bacterial infections and enhancing diabetic wound healing.