Bacterial membrane-anchored lipopeptide/MXene nanoplatform for tri-modal therapy toward bacteria-infected diabetic wound.

Diabetic wound healing is extremely difficult, originating from the aspects of bacterial infection, continuous inflammation, hypoxia and excessive reactive oxygen species (ROS), etc. Consequently, multifunctional nanoplatforms capable of highly eliminating bacteria, scavenging ROS and promoting angiogenesis possess a promising prospect. This work reports our fabrication of lipopeptide/TiCT MXene nanohybrid to cure bacteria-infected diabetic wounds. TiCT nanosheet has been employed to disrupt the bacterial membrane through both the physical puncture mediated by direct contact and mild-temperature photothermal therapy (PTT) due to its excellent photothermal conversion efficiency. Moreover, it exhibits the capacities of ROS scavenging and pro-angiogenesis during the diabetic wound healing process. Positively charged lipopeptide integration on 2D TiCT MXene improves the contact of TiCT nanosheet with negative bacterial membrane for membrane-anchoring. More importantly, drug-free lipopeptide shows antibacterial capacity, which compensates the decline in therapeutic efficacy of mild-temperature PTT because of its inferior heat intensity. The cooperation between 2D TiCT MXene and therapeutic lipopeptide allows for the effective cure on bacteria-infected diabetic wound.