Zhang Ding-Yi, Wang Meng-Xi, Cai Chuang, Cheng Wei-Wei, Cheng Yin-Jia, Liu Wen-Long, Huang Rong, Zhang Ai-Qing, Qin Si-Yong
Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, PR China.
The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, PR China.
Biomater Adv. 2025 Oct;175:214324. doi: 10.1016/j.bioadv.2025.214324. Epub 2025 May 1.
Diabetic wound healing is extremely difficult, originating from the aspects of bacterial infection, continuous inflammation, hypoxia and excessive reactive oxygen species (ROS), etc. Consequently, multifunctional nanoplatforms capable of highly eliminating bacteria, scavenging ROS and promoting angiogenesis possess a promising prospect. This work reports our fabrication of lipopeptide/TiCT MXene nanohybrid to cure bacteria-infected diabetic wounds. TiCT nanosheet has been employed to disrupt the bacterial membrane through both the physical puncture mediated by direct contact and mild-temperature photothermal therapy (PTT) due to its excellent photothermal conversion efficiency. Moreover, it exhibits the capacities of ROS scavenging and pro-angiogenesis during the diabetic wound healing process. Positively charged lipopeptide integration on 2D TiCT MXene improves the contact of TiCT nanosheet with negative bacterial membrane for membrane-anchoring. More importantly, drug-free lipopeptide shows antibacterial capacity, which compensates the decline in therapeutic efficacy of mild-temperature PTT because of its inferior heat intensity. The cooperation between 2D TiCT MXene and therapeutic lipopeptide allows for the effective cure on bacteria-infected diabetic wound.
糖尿病伤口愈合极其困难，源于细菌感染、持续炎症、缺氧和活性氧（ROS）过多等方面。因此，能够高效杀菌、清除ROS并促进血管生成的多功能纳米平台具有广阔的前景。这项工作报道了我们制备脂肽/TiCT MXene纳米杂化物以治疗细菌感染的糖尿病伤口。TiCT纳米片由于其优异的光热转换效率，已被用于通过直接接触介导的物理穿刺和温和温度光热疗法（PTT）破坏细菌膜。此外，它在糖尿病伤口愈合过程中表现出清除ROS和促进血管生成的能力。带正电荷的脂肽整合到二维TiCT MXene上可改善TiCT纳米片与带负电荷的细菌膜的接触，用于膜锚定。更重要的是，不含药物的脂肽具有抗菌能力，弥补了温和温度PTT由于热强度较低而导致的治疗效果下降。二维TiCT MXene与治疗性脂肽之间的协同作用能够有效治愈细菌感染的糖尿病伤口。
