Yao Chaofan, Wu Qian, Zhao Yu, Li Hongbin, He Jinmei, Liu Li, Huang Yudong, Cheng Feng
School of Materials Science and Engineering, School of Chemistry and Chemical Engineering, MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, Harbin Institute of Technology, Harbin 150001, PR China.
School of Materials Science and Engineering, School of Chemistry and Chemical Engineering, MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, Harbin Institute of Technology, Harbin 150001, PR China.
Int J Biol Macromol. 2025 Mar;297:139872. doi: 10.1016/j.ijbiomac.2025.139872. Epub 2025 Jan 14.
Wound bacterial infections not only impede the healing process but can also give rise to a range of serious complications, thereby posing a substantial risk to human health. Developing effective wound dressings incorporating phototherapy functionalities, specifically photothermal therapy (PTT) and photodynamic therapy (PDT), remains a critical area of research in modern wound care. Existing PTT-PDT systems often suffer from challenges such as nanoparticle aggregation and inefficient reactive oxygen species (ROS) generation, which are essential for therapeutic efficacy. This study presents a pioneering approach by combining zeolitic imidazolate framework derivatives (ZIFs) and Au NPs in a silk fibroin (SF) hydrogel for the first time. This combination not only prevents particle aggregation but also significantly enhances photothermal conversion efficiency and ROS generation capacity. The digital light processing (DLP) printability of our hydrogel allows for customized wound dressings tailored to individual patient needs, improving therapeutic efficacy. The hydrogel's effectiveness was evaluated through rigorous in vivo experiments, demonstrating enhanced antibacterial properties and accelerated wound healing. The biocompatibility of our hydrogel ensures its suitability for clinical applications, minimizing adverse reactions while promoting healing. A wound healing rate of 99.06 % represents a substantial improvement over the control groups, indicating markedly enhanced therapeutic efficacy. These findings underscore its multifunctionality in addressing infected wounds, presenting a promising strategy for facilitating the rapid healing of acute complex wounds in clinical applications.
伤口细菌感染不仅会阻碍愈合过程，还可能引发一系列严重并发症，从而对人类健康构成重大风险。开发具有光疗功能的有效伤口敷料，特别是光热疗法（PTT）和光动力疗法（PDT），仍然是现代伤口护理研究的关键领域。现有的PTT-PDT系统常常面临诸如纳米颗粒聚集和活性氧（ROS）生成效率低下等挑战，而ROS对于治疗效果至关重要。本研究首次提出了一种开创性方法，即将沸石咪唑酯骨架衍生物（ZIFs）和金纳米颗粒（Au NPs）结合在丝素蛋白（SF）水凝胶中。这种组合不仅能防止颗粒聚集，还能显著提高光热转换效率和ROS生成能力。我们的水凝胶具有数字光处理（DLP）可打印性，能够根据个体患者需求定制伤口敷料，提高治疗效果。通过严格的体内实验评估了水凝胶的有效性，结果表明其抗菌性能增强且伤口愈合加速。我们水凝胶的生物相容性确保了其适用于临床应用，在促进愈合的同时将不良反应降至最低。99.06%的伤口愈合率相较于对照组有显著提高，表明治疗效果明显增强。这些发现突出了其在处理感染伤口方面的多功能性，为临床应用中促进急性复杂伤口的快速愈合提供了一种有前景的策略。
