Cheng Lan, Chen Yue, He Jianyun, Cheng Xinxin, Wang Yuting, Lin Xiaoxia, Huang Zhenzhen, Miao Xinyi, Xia Shufang
Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Nutrients. 2025 Mar 9;17(6):957. doi: 10.3390/nu17060957.
: Depressive symptoms (DepS) are prevalent among patients with breast cancer. Offering an anti-inflammatory diet is a promising strategy for DepS management, but it is costly and difficult to scale up. Instead, anti-inflammatory dietary education is cost-effective and may be more conducive to the promotion of an anti-inflammatory diet strategy. : A prospective, assessor-blinded, two-arm randomized controlled trial was designed to determine the effects of 12-week anti-inflammatory dietary education on DepS in breast cancer patients with depression. Adult female patients with depression and receiving adjuvant chemotherapy were recruited. Participants in the intervention group received anti-inflammatory dietary education, while the control group received routine nursing care. Outcomes included the Center for Epidemiologic Studies Depression Scale (CES-D) score, energy-adjusted dietary inflammatory index (E-DII), plasma inflammatory biomarkers, and quality of life (QoL), which were all assessed at baseline and after a 12-week follow-up. The robustness of the estimates was investigated through sensitivity analyses. A post hoc power analysis was conducted to establish the observed effect sizes for the primary outcomes. : A total of 88.6% (62/70) of the participants completed the entire 12-week follow-up. No statistically significant between-group differences were found in the baseline characteristics, including sociodemographic factors, disease-related characteristics, and lifestyle factors. After the intervention, both the CES-D score ( = 0.040) and E-DII ( < 0.001) in the intervention group were significantly lower than in the control group, while the QoL was significantly increased ( < 0.001). Compared with the baseline, the tumor necrosis factor-α (TNF-α) ( = 0.002) and C-reactive protein (CRP) ( = 0.045) levels were significantly lower in the intervention group but not in the control group. : Anti-inflammatory dietary education may improve DepS and QoL in breast cancer patients with depression and undergoing chemotherapy by regulating inflammation. Given its acceptability and practicality, this strategy may be incorporated into routine cancer care.
抑郁症状（DepS）在乳腺癌患者中很常见。提供抗炎饮食是管理DepS的一种有前景的策略，但成本高昂且难以扩大规模。相反，抗炎饮食教育具有成本效益，可能更有利于促进抗炎饮食策略。：一项前瞻性、评估者盲法、双臂随机对照试验旨在确定为期12周的抗炎饮食教育对患有抑郁症的乳腺癌患者DepS的影响。招募了患有抑郁症并接受辅助化疗的成年女性患者。干预组的参与者接受抗炎饮食教育，而对照组接受常规护理。结果包括流行病学研究中心抑郁量表（CES-D）评分、能量调整饮食炎症指数（E-DII）、血浆炎症生物标志物和生活质量（QoL），这些均在基线和12周随访后进行评估。通过敏感性分析研究估计值的稳健性。进行了事后功效分析以确定主要结局的观察效应大小。：共有88.6%（62/70）的参与者完成了整个12周的随访。在基线特征方面，包括社会人口统计学因素、疾病相关特征和生活方式因素，未发现组间有统计学显著差异。干预后，干预组的CES-D评分（=0.040）和E-DII（<0.001）均显著低于对照组，而QoL显著提高（<0.001）。与基线相比，干预组的肿瘤坏死因子-α（TNF-α）（=0.002）和C反应蛋白（CRP）（=0.045）水平显著降低，而对照组则没有。：抗炎饮食教育可能通过调节炎症来改善患有抑郁症并接受化疗的乳腺癌患者的DepS和QoL。鉴于其可接受性和实用性，该策略可纳入常规癌症护理。
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