Kolivas Despina, Fraser Liz, Schweitzer Ronald, Brukner Peter, Moschonis George
School of Allied Health, Human Services & Sport, La Trobe University, Bundoora 3086, Australia.
Watson General Practice, 34 Windeyer Street, Watson 2602, Australia.
Nutrients. 2025 Mar 7;17(6):937. doi: 10.3390/nu17060937.
: Mobile health (mHealth) applications have been reported to be effective in improving glycaemic control and cardiometabolic health, but mainly as part of shorter-term intervention studies. The aim of this study is to examine the effect of the ongoing Defeat Diabetes mHealth low-carbohydrate diet (LCD) intervention on clinical markers and cardiometabolic risk after 6 months of intervention. : Data were collected via primary care physicians as part of routine T2D monitoring. These included HbA1c (primary outcome), blood pressure, blood lipids, and markers of kidney and liver function. Anthropometrics, as well as changes in the prescription of diabetes, hypertension, and dyslipidaemia medication, were also recorded. Calculated variables, total cholesterol to HDL-c, triglyceride to HDL-c, and waist to height ratios, were analysed to examine changes in cardiometabolic risk profile. Three-day food records were used to assess dietary intake and intervention adherence. Univariate regression models examined changes from baseline to 6 months. : Ninety-four participants remained in the study out of the ninety-nine at baseline (mean age 59 ± 11 years, 55 females). After 6 months of intervention, there were significant reductions in HbA1c by -1.0% (95% CI: -1.3 to -0.6), as well as in the liver enzymes ALT (-9.3 U/L 95% CI -16.3 to -2.4) and GGT (-18.8 U/L 95% CI: -31.4 to -6.3) across the cohort. In addition, there was a significant reduction in cardiometabolic risk, as measured by the calculated variables and a decrease in waist circumference (-4.6 cm 95% CI: -8.9 to -0.2). : People with T2D receiving LCD education and resources through the Defeat Diabetes mHealth app (version 3.3.8) improved their glycaemic control after 6 months of intervention. Cardiometabolic risk profile and liver function also showed significant improvement. These findings indicate that the use of an LCD digital app is a valuable adjunct in the management of T2D.
据报道，移动健康（mHealth）应用程序在改善血糖控制和心脏代谢健康方面有效，但主要是作为短期干预研究的一部分。本研究的目的是探讨正在进行的“战胜糖尿病”mHealth低碳水化合物饮食（LCD）干预6个月后对临床指标和心脏代谢风险的影响。
数据通过初级保健医生收集，作为2型糖尿病常规监测的一部分。这些数据包括糖化血红蛋白（主要结果）、血压、血脂以及肝肾功能指标。还记录了人体测量数据以及糖尿病、高血压和血脂异常药物处方的变化。分析计算变量，即总胆固醇与高密度脂蛋白胆固醇之比、甘油三酯与高密度脂蛋白胆固醇之比以及腰高比，以检查心脏代谢风险状况的变化。采用三天食物记录来评估饮食摄入量和干预依从性。单变量回归模型检查了从基线到6个月的变化。
在基线时的99名参与者中，有94名留在了研究中（平均年龄59±11岁，55名女性）。干预6个月后，整个队列的糖化血红蛋白显著降低了-1.0%（95%置信区间：-1.3至-0.6），谷丙转氨酶（ALT）（-9.3 U/L，95%置信区间-16.3至-2.4）和谷氨酰转肽酶（GGT）（-18.8 U/L，95%置信区间：-31.4至-6.3）也显著降低。此外，通过计算变量衡量的心脏代谢风险显著降低，腰围减小（-4.6 cm，95%置信区间：-8.9至-0.2）。
通过“战胜糖尿病”mHealth应用程序（3.3.8版）接受LCD教育和资源的2型糖尿病患者在干预6个月后改善了血糖控制。心脏代谢风险状况和肝功能也有显著改善。这些发现表明，使用LCD数字应用程序是2型糖尿病管理中有价值的辅助手段。
