干燥综合征对不良妊娠结局影响的荟萃分析。
A meta-analysis of the effect of Sjögren's syndrome on adverse pregnancy outcomes.
机构信息
Department of Rheumatology and Immunology, Ningbo Huamei hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
Department of Rheumatology and Immunology, Ningbo Huamei hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
出版信息
Clinics (Sao Paulo). 2022 Nov 17;77:100140. doi: 10.1016/j.clinsp.2022.100140. eCollection 2022.
OBJECTIVE
This study aimed to assess the correlation between Sjögren's Syndrome (SS) and adverse pregnancy outcomes, with the aim of providing a basis for preconception and pregnancy interventions in women with SS.
METHODS
A search of electronic databases in English and Chinese databases from January 2005 to December 2021, was conducted to collect the literature of case-control studies or cohort studies on the association between SS and pregnancy outcome studies. Literature inclusion and data extraction were performed according to established criteria, and the Newcastle-Ottawa scale was used to evaluate the quality of the literature. Stata 15 software was used for meta-analysis.
RESULTS
A total of nine papers were included in this study. Meta-analysis results showed that SS was associated with spontaneous abortion (RR = 8.85, 95% CI 3.10‒25.26), preterm birth (RR = 2.27, 95% CI 1.46‒3.52), low birth mass (RR = 1.99, 95% CI 1.34‒2.97), and birth defects (RR = 4.28, 95% CI 3.08‒5.96).
CONCLUSION
SS can increase the incidence of adverse pregnancy outcomes.
目的
本研究旨在评估干燥综合征（SS）与不良妊娠结局之间的相关性，旨在为 SS 患者的孕前和妊娠干预提供依据。
方法
检索 2005 年 1 月至 2021 年 12 月的英文和中文电子数据库，收集 SS 与妊娠结局相关性的病例对照研究或队列研究文献。根据既定标准进行文献纳入和数据提取，并使用纽卡斯尔-渥太华量表评估文献质量。使用 Stata 15 软件进行荟萃分析。
结果
本研究共纳入 9 篇文献。荟萃分析结果表明，SS 与自然流产（RR=8.85，95%CI 3.10-25.26）、早产（RR=2.27，95%CI 1.46-3.52）、低出生体重儿（RR=1.99，95%CI 1.34-2.97）和出生缺陷（RR=4.28，95%CI 3.08-5.96）有关。
结论
SS 可增加不良妊娠结局的发生率。
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