Brückner O, Trautmann M, Borner K
Drugs. 1985;29 Suppl 5:162-6. doi: 10.2165/00003495-198500295-00033.
Temocillin concentrations in serum and cerebrospinal fluid (CSF) samples from 8 patients were assayed by high pressure liquid chromatography. It was possible to determine sequential series of ventricular (CSF) and serum concentrations in 4 adult neurosurgical patients with slight to moderate impairment of blood-CSF barriers, because serial CSF samples were obtained from external ventricular drains. In 4 other patients with meningitis, temocillin was given in addition to the regular treatment schedule and 6 'spot' concentrations of temocillin in lumbar CSF and serum samples were determined. Temocillin CSF concentrations in these subjects seemed to be inadequate for the treatment of Gram-positive bacterial meningitis and only partially valuable for the treatment of Gram-negative bacillary meningitis.
采用高压液相色谱法测定了8例患者血清和脑脊液（CSF）样本中的替莫西林浓度。对于4例血脑屏障轻度至中度受损的成年神经外科患者，由于通过外部脑室引流管获取了系列脑脊液样本，因此能够测定脑室（CSF）和血清浓度的连续系列值。在另外4例脑膜炎患者中，除常规治疗方案外还给予了替莫西林，并测定了腰椎脑脊液和血清样本中替莫西林的6个“即时”浓度。这些受试者的替莫西林脑脊液浓度似乎不足以治疗革兰氏阳性菌脑膜炎，对治疗革兰氏阴性杆菌性脑膜炎仅有部分价值。
