Yalamanchili Satish, Aboughaida Ali, Rohani Omid S, Dyk David William
Alcon Research LLC, Lake Forest, CA, USA.
Clin Ophthalmol. 2025 Apr 23;19:1357-1364. doi: 10.2147/OPTH.S516801. eCollection 2025.
To compare surge volume after occlusion breaks in five phacoemulsification systems.
A mechanical spring-eye model was used to evaluate the Legion™ Vision System with the Single Use Fluidics Management System (FMS) (LEG), Infiniti™ Vision System with Intrepid™ Plus FMS (INF), Whitestar Signature Pro with the OPO73 pack (WSP), Compact Intuitiv with the OPO80 pack (CIS), and Stellaris PC with the StableChamber cassette (SPC). Transient occlusion break surge volume responses were assessed across a full range of system settings (IOP: 30 to 80 mmHg; vacuum limit: 300 to 650 mmHg; aspiration rate: 20 or 40 cc/min. Oscilloscope waveforms covered stable flow before occlusion, full occlusion, occlusion break, and full recovery to stable flow. Raw oscilloscope data were converted to volumetric and pressure measurements. Fitted average surge traces were generated for each test condition and used to develop an interpolation algorithm to predict transient occlusion break surge events.
The minimum surge volume for all systems occurred at the highest IOP (80 mmHg) and the lowest tested vacuum limit (300 mmHg). Overall, the surge volume increased with increasing vacuum limit and decreasing IOP on the LEG, INF CIS, WSP, and SPC systems. The occlusion break surge volumes (µL [standard deviation]) at 60 mmHg IOP and vacuum limit of 500 mmHg were 70.4 [8.1] for LEG; 87.4 [9.7] for INF; 85.8 [7.2] for CIS; 69.5 [5.0] for WSP; and 151.7 [20.2]) for SPC. A Games-Howell post-hoc test showed significant differences between three groups: A) LEG/WSP, B) CIS/INF, and C) SPC.
The Legion system demonstrated comparable or lower predicted surge volume after occlusion breaks compared to the other phacoemulsification systems evaluated. Reductions in occlusion break surge volumes are expected to decrease the rate of complications and lead to improved outcomes in the clinical cataract surgery setting.
比较五种超声乳化系统在阻塞解除后的浪涌体积。
使用机械弹簧眼模型评估配备一次性流体管理系统（FMS）的Legion™视觉系统（LEG）、配备Intrepid™ Plus FMS的Infiniti™视觉系统（INF）、配备OPO73组件的Whitestar Signature Pro（WSP）、配备OPO80组件的Compact Intuitiv（CIS）以及配备StableChamber盒式装置的Stellaris PC（SPC）。在所有系统设置范围内（眼压：30至80 mmHg；真空极限：300至650 mmHg；抽吸速率：20或40 cc/min）评估瞬态阻塞解除浪涌体积响应。示波器波形涵盖阻塞前的稳定流动、完全阻塞、阻塞解除以及恢复到稳定流动的全过程。原始示波器数据被转换为体积和压力测量值。针对每个测试条件生成拟合平均浪涌轨迹，并用于开发一种插值算法以预测瞬态阻塞解除浪涌事件。
所有系统的最小浪涌体积出现在最高眼压（80 mmHg）和最低测试真空极限（300 mmHg）时。总体而言，LEG、INF、CIS、WSP和SPC系统的浪涌体积随真空极限增加和眼压降低而增大。在眼压为60 mmHg且真空极限为500 mmHg时，LEG的阻塞解除浪涌体积（微升[标准差]）为70.4 [8.1]；INF为87.4 [9.7]；CIS为85.8 [7.2]；WSP为69.5 [5.0]；SPC为151.7 [20.2]。Games-Howell事后检验显示三组之间存在显著差异：A）LEG/WSP，B）CIS/INF，C）SPC。
与其他评估的超声乳化系统相比，Legion系统在阻塞解除后显示出相当或更低的预测浪涌体积。预计阻塞解除浪涌体积的减少将降低并发症发生率，并在临床白内障手术中带来更好的结果。
