Onnis A, Nardelli G B, Lamaina V, Mozzanega B, Becagli L, Fais G F
Eur J Gynaecol Oncol. 1985;6(2):125-8.
Since 1982 we have been associating the study of hormonal receptors with the histological examination of the vulvar lesions in an attempt to interpret the action mechanism of steroids on the vulva, to find possible correlations between histological pictures and receptorial order and to find a possible predictive "marker" toward therapeutic and prognostic ends. In our Laboratory assays for androgen, estrogen and progesterone receptors were performed with the Dextran-Charcoal technique in 41 patients with vulvar dystrophy; 20 of whom had atrophic dystrophy and 21 with hypertrophic dystrophy. Another 24 patients with vulvar carcinoma were studied; 23 with epidermoid carcinoma of various differentiation grades and only one case of Paget's Disease. None of the three receptors assayed could be considered a predictive or prognostic marker in the approach to neoplastic forms. The levels of the progesterone receptor appears increased in the case of dystrophies. This justifies the hypothesis of a hormonal involvement in the pathogenesis of the lesion, as has already been documented by the beneficial effects of therapy with topical steroids.
自1982年以来，我们一直将激素受体的研究与外阴病变的组织学检查相结合，试图解释类固醇对外阴的作用机制，寻找组织学图像与受体状态之间可能的相关性，并找到一个可能用于治疗和预后的预测性“标志物”。在我们实验室，采用葡聚糖-活性炭技术对41例外阴营养不良患者进行了雄激素、雌激素和孕激素受体检测；其中20例为萎缩性营养不良，21例为肥厚性营养不良。另外还研究了24例外阴癌患者；23例为不同分化程度的表皮样癌，仅1例为佩吉特病。在所检测的三种受体中，没有一种可被视为肿瘤形式研究中的预测或预后标志物。在营养不良的情况下，孕激素受体水平似乎有所升高。这证明了激素参与病变发病机制的假说，局部类固醇治疗的有益效果已证实了这一点。
