Becagli L, Scrimin F, De Salvia D, Gambato M, Resta P, Ambrosini A
Clin Exp Obstet Gynecol. 1983;10(2-3):145-9.
Hormone receptor assays for testosterone, estrogens and androgens were performed on 53 biopsy specimens of vulva from 40 patients, consisting of 6 with normal tissue, 14 with atrophic type dystrophy, 13 with hypertrophic type dystrophy, and 20 with malignancy. Atrophic and hypertrophic forms showed a different receptor pattern; hypertrophic forms were characterized by consistently higher levels of progesterone receptors not correlated with estrogen receptors. Neoplastic tissue showed no significant changes in values compared to normal or dystrophic forms, but range of variability was high. The bond between neoplastic forms and hormone activity seems without doubt less important than in the corresponding endometrial and mammary forms. The study of dystrophic forms, instead, should be further explored with a larger number of cases.
对40例患者的53份外阴活检标本进行了睾酮、雌激素和雄激素的激素受体检测，其中包括6例正常组织、14例萎缩型营养不良、13例肥厚型营养不良和20例恶性肿瘤。萎缩型和肥厚型表现出不同的受体模式；肥厚型的特征是孕激素受体水平持续较高，与雌激素受体无关。与正常或营养不良形式相比，肿瘤组织的值没有显著变化，但变异范围较大。肿瘤形式与激素活性之间的联系似乎无疑比相应的子宫内膜和乳腺形式中的联系不那么重要。相反，对于营养不良形式的研究应该用更多的病例进一步探索。
