Onnis A, Nardelli G B, Becagli L, Maggino T, Marchetti M
Clin Exp Obstet Gynecol. 1983;10(4):159-65.
Assays have been developed for the quantitation of androgen, estrogen and progesterone receptors in the cytosol of 45 vulvar dystrophic tissues. In 27 patients we assayed only cytoplasmatic receptors, while in 18 patients both cytoplasmatic and nuclear receptors. The workers verified the possibility to assay these carriers, finding significant correlations neither with patient's age nor between atrophic and hypertrophic dystrophies. The research concerning the cytoplasmatic depletion and nuclear accumulation allowed us to understand the action mechanism of the androgen in vulvar tissues in patients in menopause.
已开发出用于定量检测45例外阴营养不良组织胞浆中雄激素、雌激素和孕激素受体的检测方法。在27例患者中，我们仅检测了细胞质受体，而在18例患者中同时检测了细胞质和细胞核受体。研究人员验证了检测这些载体的可能性，发现其与患者年龄以及萎缩性和肥厚性营养不良之间均无显著相关性。关于细胞质消耗和细胞核积累的研究使我们能够了解雄激素在绝经后患者外阴组织中的作用机制。
