Bortolotti M, Abbati A, Turba E, Pozzato R, Bersani G, Labò G
Eur J Nucl Med. 1985;10(11-12):549-50. doi: 10.1007/BF00252750.
In 5 patients with partial gastric resection and esophagitis, in whom esophageal pH metry was unable to demonstrate significant gastroesophageal reflux (GER), we administered i.v. 5 mCi (185 MBq) of 99mTc-HIDA, the patient lying under a computer-assisted LFOV gamma camera. When gallbladder image was evident, caerulein was administered i.v. at a physiologic dose in order to induce gallbladder contraction, and in the subsequent 45 min the patient was asked to perform a standard series of manoeuvres that increase the intraabdominal pressure (Valsalva, etc.) and favour GER. Scintigraphic images and time/activity curves obtained from areas of interest corresponding to gastric remnant and distal esophagus showed that at least one of these manoeuvres in each case was followed by the appearance of the radiocompound in the distal esophagus, indicating a 99mTc-HIDA-tagged bile GER. Consequently, we believe that HIDA-GER dynamic scintigraphy may be more useful than esophageal pH metry in demonstrating the biliary origin of an esophagitis.
在5例接受部分胃切除术且患有食管炎的患者中，食管pH测定未能显示出明显的胃食管反流（GER），我们静脉注射了5毫居里（185兆贝可）的99m锝-二乙基乙酰苯胺亚氨基二乙酸（99mTc-HIDA），患者躺在计算机辅助的大视野γ相机下。当胆囊图像清晰可见时，静脉注射生理剂量的缩胆囊素以诱导胆囊收缩，在随后的45分钟内，要求患者进行一系列标准动作以增加腹内压（瓦尔萨尔瓦动作等）并促进胃食管反流。从与胃残余和食管远端相对应的感兴趣区域获得的闪烁图像和时间/活性曲线显示，在每种情况下，至少有一个动作之后放射性化合物出现在食管远端，表明存在99mTc-HIDA标记的胆汁反流性胃食管反流。因此，我们认为HIDA-胃食管反流动态闪烁扫描在证明食管炎的胆汁来源方面可能比食管pH测定更有用。
