Tolin R D, Malmud L S, Stelzer F, Menin R, Makler P T, Applegate G, Fisher R S
Gastroenterology. 1979 Nov;77(5):1027-33.
Initially, scintigraphy was established as a valid method for detecting and quantitating enterogastric reflux. A new, tubeless technique for the measurement of enterogastric reflux was developed. 99mTc bound to [(2,6 dimethylphenylcarbamoylmethyl) iminodiacetic acid] (5 mCi) was administered intravenously to visualize the liver and biliary tract. One hour later, a standard liquid meal labeled with 111In bound to diethylene-triamine penta-acetic acid (250 microCi) was given. The 99mTc and 111In activities were recorded simultaneously for 1-min periods at 15-min intervals for 2 hr over liver, gallbladder, and gastric areas of interest. Enterogastric reflux indices were determined. Ten normal subjects and 13 patients with vagotomy, hemigastrectomy, and Bilroth II gastrojejunostomy were evaluated. The enterogastric reflux index in asymptomatic postsurgical patients was increased significantly to 24.6 +/- 4.7 compared with 8.2 +/- 6.0 (P less than 0.01) in normal subjects. In postsurgical patients with the syndrome of alkaline gastritis, the enterogastric reflux index was increased significantly to 86.3 +/- 7.1 (P less than 0.01) compared with asymptomatic postsurgical patients.
最初，闪烁扫描术被确立为检测和定量肠胃反流的有效方法。一种用于测量肠胃反流的新型无管技术被开发出来。将与[(2,6 - 二甲基苯基氨基甲酰甲基)亚氨基二乙酸]结合的99mTc（5毫居里）静脉注射，以可视化肝脏和胆道。一小时后，给予含有与二乙烯三胺五乙酸结合的111In标记的标准流质餐（250微居里）。在2小时内，以15分钟的间隔，在肝脏、胆囊和胃部感兴趣区域同时记录99mTc和111In的活性1分钟。确定肠胃反流指数。对10名正常受试者以及13名接受迷走神经切断术、半胃切除术和毕罗Ⅱ式胃空肠吻合术的患者进行了评估。无症状术后患者的肠胃反流指数显著增加至24.6±4.7，而正常受试者为8.2±6.0（P＜0.01）。在患有碱性胃炎综合征的术后患者中，肠胃反流指数与无症状术后患者相比显著增加至86.3±7.1（P＜0.01）。
