Parrott A C, Jones R
Eur J Clin Pharmacol. 1985;28(4):419-23. doi: 10.1007/BF00544360.
The effects of transdermal scopolamine upon objective psychological performance assessments and self reports of feeling states, were investigated with volunteer subjects at sea. Scopolamine and placebo patches were administered on consecutive days in a counterbalanced order. Psychological performance was assessed 24 h following each transdermal patch. Choice reaction time and code substitution performance levels were not significantly changed, but letter cancellation errors were significantly more frequent following transdermal scopolamine. Transdermal scopolamine caused significantly more reports of dry mouth. More subjects were also unable to undertake the performance tests following scopolamine than placebo, due to difficulties in focusing on the test materials. However despite deleterious side effects with some personnel, others responded positively to the scopolamine patch. As noted by other workers, responses to the transdermal scopolamine patch seem to be quite variable.
在海上对志愿者受试者研究了透皮东莨菪碱对客观心理表现评估及感觉状态自我报告的影响。东莨菪碱贴片和安慰剂贴片以平衡顺序连续数天给药。在每次透皮贴片后24小时评估心理表现。选择反应时间和代码替换表现水平没有显著变化，但透皮给予东莨菪碱后字母划消错误明显更频繁。透皮东莨菪碱导致口干报告显著增多。由于难以专注于测试材料，与安慰剂相比，更多受试者在使用东莨菪碱后无法进行性能测试。然而，尽管对一些人员有不良副作用，但其他人员对东莨菪碱贴片反应积极。正如其他研究人员所指出的，对透皮东莨菪碱贴片的反应似乎差异很大。
