Melancon Sophie T, San Valentin Erin Marie, Bolinas Dominic Karl M, Bernardino Marvin R, Mishra Archana, Canlas Gino, Chintalapani Gouthami, Jacobsen Megan C, Barcena Allan John R, Huang Steven Y
Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.
Polymers (Basel). 2025 Mar 7;17(6):716. doi: 10.3390/polym17060716.
Resorbable medical devices provide temporary functionality before degrading into safe byproducts. One application is absorbable inferior vena cava filters (IVCFs), which prevent pulmonary embolism in high-risk patients with contraindications to anticoagulants. However, current absorbable IVCFs are limited by radiolucency and local clot formation risks. This study aimed to develop radiopaque, drug-loaded resorbable IVCFs with enhanced imaging and therapeutic capabilities. Poly-p-dioxanone (PPDO) sutures were infused with gadolinium nanoparticles (GdNPs) and dipyridamole (DPA), an anti-thrombotic agent. GdNPs were synthesized with an average diameter of 35.76 ± 3.71 nm. Gd content was 371 ± 1.6 mg/g (PPDO-Gd) and 280 ± 0.3 mg/g (PPDO-Gd + DPA), while the DPA content was 18.20 ± 5.38 mg/g (PPDO-DPA) and 12.91 ± 0.83 mg/g (PPDO-Gd + DPA). Suture thickness (0.39-0.49 cm, = 0.0143) and melting temperature (103.61-105.90, = 0.0002) statistically differed among the different groups, while load-at-break did not (4.39-5.38, = 0.2367). Although suture thickness and melting temperatures differed significantly, load-at-break was preserved and did not alter the mechanical and degradation properties of the various IVCFs. Micro-computed tomography revealed enhanced radiopacity for Gd-containing IVCFs (2713 ± 105 HU for PPDO-Gd, 1516 ± 281 HU for PPDO-Gd + DPA). Radiopacity decreased gradually over 10-12 weeks. Clot-trapping efficacy was maintained, and no hemolysis or cellular toxicity was observed. In conclusion, the GdNP- and DPA-infused PPDO IVCFs demonstrated improved radiopacity, anti-thrombotic potential, and compatibility with routine imaging, without compromising mechanical strength or safety.
可吸收医疗设备在降解为安全的副产物之前提供临时功能。一种应用是可吸收下腔静脉滤器（IVCFs），其可预防对抗凝剂有禁忌证的高危患者发生肺栓塞。然而，目前的可吸收IVCFs受到射线可透性和局部血栓形成风险的限制。本研究旨在开发具有增强成像和治疗能力的不透射线、载药可吸收IVCFs。聚对二氧环己酮（PPDO）缝线中注入了钆纳米颗粒（GdNPs）和抗血栓药物双嘧达莫（DPA）。合成的GdNPs平均直径为35.76±3.71nm。Gd含量为371±1.6mg/g（PPDO-Gd）和280±0.3mg/g（PPDO-Gd+DPA），而DPA含量为18.20±5.38mg/g（PPDO-DPA）和12.91±0.83mg/g（PPDO-Gd+DPA）。不同组之间缝线厚度（0.39 - 0.49cm， = 0.0143）和熔点（103.61 - 105.90， = 0.0002）在统计学上存在差异，而断裂载荷没有差异（4.39 - 5.38， = 0.2367）。尽管缝线厚度和熔点有显著差异，但断裂载荷得以保留，且未改变各种IVCFs的机械性能和降解性能。微型计算机断层扫描显示含Gd的IVCFs射线不透性增强（PPDO-Gd为2713±105HU，PPDO-Gd+DPA为1516±281HU）。射线不透性在10 - 12周内逐渐降低。血栓捕获效果得以维持，且未观察到溶血或细胞毒性。总之，注入GdNP和DPA的PPDO IVCFs表现出改善的射线不透性、抗血栓潜力以及与常规成像的兼容性，同时不影响机械强度或安全性。
