血浆或血清中米诺环素的快速荧光测定法：与微生物测定法的比较。
Rapid fluorimetric assay of minocycline in plasma or serum: comparison with microbiological assay.
作者信息
Hall D
出版信息
Br J Clin Pharmacol. 1977 Feb;4(1):57-60. doi: 10.1111/j.1365-2125.1977.tb00667.x.
Abstract
- Plasma concentrations of minocycline were assayed by measuring the fluorescence emission of an aluminum-minocycline chelate in a spectrofluorimeter. 2. The assay gives reproducible results over the concentration range 0.05-5.0 mug ml-1, and compared favourably with results achieved using a conventional large plate agar diffusion microbiological assay in a double-blind comparison of the two methods. 3. Fluorimetric assay of minocycline in plasma was found to correlate closely with antibiotic activity (r = 0.95). The method is easy and economical to perform, results being obtained in 1 h.
摘要
- 通过在荧光分光光度计中测量铝-米诺环素螯合物的荧光发射来测定血浆中米诺环素的浓度。2. 该测定法在0.05 - 5.0微克/毫升的浓度范围内可得到可重复的结果，并且在两种方法的双盲比较中，与使用传统的大板琼脂扩散微生物测定法所获得的结果相比更具优势。3. 发现血浆中米诺环素的荧光测定法与抗生素活性密切相关（r = 0.95）。该方法操作简便且经济，1小时内即可获得结果。
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Rapid fluorimetric assay of minocycline in plasma or serum: comparison with microbiological assay.血浆或血清中米诺环素的快速荧光测定法：与微生物测定法的比较。
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本文引用的文献
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Clinical evaluation of minocycline.米诺环素的临床评估。
Antimicrob Agents Chemother (Bethesda). 1968;8:335-9.
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Clinical pharmacologic studies with minocycline.
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Quality control of serum gentamicin assays--experience of national surveys.
J Antimicrob Chemother. 1975 Mar;1(1):103-16. doi: 10.1093/jac/1.1.103.
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Fluorimetric assay of tetracycline mixtures.
J Pharm Pharmacol. 1976 May;28(5):420-3. doi: 10.1111/j.2042-7158.1976.tb04646.x.
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