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1
Rapid fluorimetric assay of minocycline in plasma or serum: comparison with microbiological assay.血浆或血清中米诺环素的快速荧光测定法：与微生物测定法的比较。
Br J Clin Pharmacol. 1977 Feb;4(1):57-60. doi: 10.1111/j.1365-2125.1977.tb00667.x.
2
Effects of serum lipid content on the binding of minocycline.血清脂质含量对米诺环素结合的影响。
J Antibiot (Tokyo). 1977 Jul;30(7):593-6. doi: 10.7164/antibiotics.30.593.
3
Fluorimetric assay of tetracycline mixtures.
J Pharm Pharmacol. 1976 May;28(5):420-3. doi: 10.1111/j.2042-7158.1976.tb04646.x.
4
Liquid chromatographic determination of minocycline in human serum.液相色谱法测定人血清中的米诺环素
J Pharm Sci. 1979 Dec;68(12):1527-30. doi: 10.1002/jps.2600681217.
5
Serum minocycline kinetics in children.
Indian J Med Res. 1980 May;71:764-7.
6
Fluorometric determination of tetracyclines in small blood and tissue samples.
J Pharm Sci. 1981 Feb;70(2):186-9. doi: 10.1002/jps.2600700218.
7
Absorption of minocycline hydrochloride and tetracycline hydrochloride. Effect of food, milk, and iron.盐酸米诺环素和盐酸四环素的吸收。食物、牛奶和铁的影响。
J Am Acad Dermatol. 1985 Feb;12(2 Pt 1):308-12. doi: 10.1016/s0190-9622(85)80041-4.
8
Measurement of tetracycline levels in parakeets.虎皮鹦鹉体内四环素水平的测量。
Avian Dis. 1984 Jan-Mar;28(1):295-302.
9
Ovine pulmonary transit of tetracycline and minocycline.四环素和米诺环素在绵羊肺部的转运
Diagn Microbiol Infect Dis. 1987 Jan;6(1):53-8. doi: 10.1016/0732-8893(87)90114-3.
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Pharmacokinetics of minocycline hydrochloride in clinically normal and hypoproteinemic sheep.盐酸米诺环素在临床正常和低蛋白血症绵羊体内的药代动力学
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引用本文的文献

1
Cardiac uptake of minocycline and mechanisms for in vivo cardioprotection.米诺环素的心脏摄取及体内心脏保护机制。
J Am Coll Cardiol. 2008 Sep 23;52(13):1086-94. doi: 10.1016/j.jacc.2008.06.028.

本文引用的文献

1
Clinical evaluation of minocycline.米诺环素的临床评估。
Antimicrob Agents Chemother (Bethesda). 1968;8:335-9.
2
Clinical pharmacologic studies with minocycline.
J Clin Pharmacol New Drugs. 1971 Sep-Oct;11(5):332-48.
3
Quality control of serum gentamicin assays--experience of national surveys.
J Antimicrob Chemother. 1975 Mar;1(1):103-16. doi: 10.1093/jac/1.1.103.
4
Fluorimetric assay of tetracycline mixtures.
J Pharm Pharmacol. 1976 May;28(5):420-3. doi: 10.1111/j.2042-7158.1976.tb04646.x.

血浆或血清中米诺环素的快速荧光测定法：与微生物测定法的比较。

Rapid fluorimetric assay of minocycline in plasma or serum: comparison with microbiological assay.

作者信息

Hall D

出版信息

Br J Clin Pharmacol. 1977 Feb;4(1):57-60. doi: 10.1111/j.1365-2125.1977.tb00667.x.

DOI:10.1111/j.1365-2125.1977.tb00667.x
PMID:402926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1428976/
Abstract
  1. Plasma concentrations of minocycline were assayed by measuring the fluorescence emission of an aluminum-minocycline chelate in a spectrofluorimeter. 2. The assay gives reproducible results over the concentration range 0.05-5.0 mug ml-1, and compared favourably with results achieved using a conventional large plate agar diffusion microbiological assay in a double-blind comparison of the two methods. 3. Fluorimetric assay of minocycline in plasma was found to correlate closely with antibiotic activity (r = 0.95). The method is easy and economical to perform, results being obtained in 1 h.
摘要
  1. 通过在荧光分光光度计中测量铝-米诺环素螯合物的荧光发射来测定血浆中米诺环素的浓度。2. 该测定法在0.05 - 5.0微克/毫升的浓度范围内可得到可重复的结果，并且在两种方法的双盲比较中，与使用传统的大板琼脂扩散微生物测定法所获得的结果相比更具优势。3. 发现血浆中米诺环素的荧光测定法与抗生素活性密切相关（r = 0.95）。该方法操作简便且经济，1小时内即可获得结果。