组蛋白基因在小鼠 - 人杂交细胞中的选择性表达。

Selective expression of histone genes in mouse-human hybrid cells.

作者信息

Marashi F, Croce C M, Stein J L, Stein G S

出版信息

Exp Cell Res. 1985 Aug;159(2):280-6. doi: 10.1016/s0014-4827(85)80002-1.

Abstract

Mouse-human hybrid cells preferentially segregating mouse chromosomes contain predominantly human histone mRNAs and synthesize human histone proteins. In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These results suggest transcriptional control of histone gene expression in hybrids segregating mouse chromosomes and post-transcriptional regulation in hybrids segregating human chromosomes.

摘要

优先分离小鼠染色体的小鼠 - 人杂交细胞主要含有人类组蛋白mRNA并合成人类组蛋白。相反，分离人类染色体的杂交细胞同时含有人类和小鼠组蛋白mRNA，但只合成小鼠组蛋白。这些结果表明，在分离小鼠染色体的杂交细胞中存在组蛋白基因表达的转录控制，而在分离人类染色体的杂交细胞中存在转录后调控。