位于1号染色体长臂上的一个主要人类组蛋白基因簇。
A major human histone gene cluster on the long arm of chromosome 1.
作者信息
Green L, Van Antwerpen R, Stein J, Stein G, Tripputi P, Emanuel B, Selden J, Croce C
出版信息
Science. 1984 Nov 16;226(4676):838-40. doi: 10.1126/science.6494913.
PMID:6494913
Abstract
A human histone gene cluster was assigned to chromosome 1 by Southern blot analysis of DNA's from a series of mouse-human somatic cell hybrids with 32P-labeled cloned human H4 and H3 histone DNA as probes. Localization of this histone gene cluster on the long arm of chromosome 1 was confirmed by in situ hybridization of this DNA probe to metaphase chromosomes.
摘要
通过以32P标记的克隆人H4和H3组蛋白DNA为探针，对一系列小鼠-人类体细胞杂种的DNA进行Southern印迹分析，将一个人类组蛋白基因簇定位到了1号染色体上。通过将该DNA探针与中期染色体进行原位杂交，证实了这个组蛋白基因簇位于1号染色体长臂上。
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