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FLT3突变型急性髓系白血病干细胞移植后的酪氨酸激酶抑制剂维持治疗。

Tyrosine kinase inhibitor maintenance therapy after stem cell transplantation for FLT3-mutated acute myeloid leukemia.

作者信息

Chen Po-Huang, Jhou Hong-Jie, Lee Cho-Hao

机构信息

Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan.

出版信息

Cochrane Database Syst Rev. 2025 Apr 28;4(4):CD016090. doi: 10.1002/14651858.CD016090.

DOI:10.1002/14651858.CD016090
PMID:40292732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12036002/
Abstract

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of FLT3 TKIs as maintenance therapy compared to no maintenance therapy or alternative strategies for participants with FLT3-mutated AML after allo-HSCT.

摘要

这是一项Cochrane系统评价(干预措施)的方案。目标如下:评估与不进行维持治疗或异基因造血干细胞移植后FLT3突变急性髓系白血病参与者的替代策略相比,FLT3酪氨酸激酶抑制剂作为维持治疗的效果。

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本文引用的文献

1
Quizartinib plus chemotherapy in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia (QuANTUM-First): a randomised, double-blind, placebo-controlled, phase 3 trial.Quizartinib 联合化疗治疗新诊断的 FLT3 内部串联重复阳性急性髓系白血病患者(QuANTUM-First):一项随机、双盲、安慰剂对照、3 期临床试验。
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FLT3 inhibitors as maintenance therapy post allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with FLT3 mutations: A meta-analysis.FLT3 抑制剂作为伴有 FLT3 突变的急性髓系白血病患者异基因造血干细胞移植后维持治疗的疗效:一项荟萃分析。
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Overcoming Resistance: FLT3 Inhibitors Past, Present, Future and the Challenge of Cure.克服耐药性:FLT3抑制剂的过去、现在、未来与治愈挑战
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Relapse after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia: an overview of prevention and treatment.异基因造血干细胞移植后急性髓系白血病的复发:预防和治疗概述。
Int J Hematol. 2022 Sep;116(3):330-340. doi: 10.1007/s12185-022-03416-7. Epub 2022 Jul 16.
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Safety of FLT3 inhibitors in patients with acute myeloid leukemia.FLT3 抑制剂在急性髓细胞白血病患者中的安全性。
Expert Rev Hematol. 2021 Sep;14(9):851-865. doi: 10.1080/17474086.2021.1969911. Epub 2021 Aug 30.
6
FLT3 Tyrosine Kinase Inhibitors for the Treatment of Fit and Unfit Patients with FLT3-Mutated AML: A Systematic Review.用于治疗FLT3突变型急性髓系白血病(AML)的适合与不适合患者的FLT3酪氨酸激酶抑制剂:一项系统评价
Int J Mol Sci. 2021 May 30;22(11):5873. doi: 10.3390/ijms22115873.
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The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.PRISMA 2020 声明:系统评价报告的更新指南。
BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71.
8
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Haematologica. 2021 Mar 1;106(3):664-670. doi: 10.3324/haematol.2019.240747.
9
NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021.NCCN 指南解读:急性髓系白血病,第 2.2021 版。
J Natl Compr Canc Netw. 2021 Jan 6;19(1):16-27. doi: 10.6004/jnccn.2021.0002.
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Sorafenib maintenance in patients with FLT3-ITD acute myeloid leukaemia undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised phase 3 trial.索拉非尼维持治疗伴 FLT3-ITD 急性髓系白血病行异基因造血干细胞移植患者:一项开放标签、多中心、随机 3 期临床试验。
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