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大脑虽小,但挑战巨大:早年样本中的白质纤维束成像

Small brains but big challenges: white matter tractography in early life samples.

作者信息

Dubois Jessica, Grotheer Mareike, Yang Joseph Yuan-Mou, Tournier Jacques-Donald, Beaulieu Christian, Lebel Catherine

机构信息

Université Paris Cité, Inserm, Paris, F-75019, NeuroDiderot, France.

Université Paris-Saclay, CEA, UNIACT, Gif-sur-Yvette, F-91191, NeuroSpin, France.

出版信息

Brain Struct Funct. 2025 Apr 28;230(4):58. doi: 10.1007/s00429-025-02922-8.

DOI:10.1007/s00429-025-02922-8
PMID:40293528
Abstract

In the human brain, white matter development is a complex and long-lasting process involving intermingling micro- and macrostructural mechanisms, such as fiber growth, pruning and myelination. Did you know that all these neurodevelopmental changes strongly affect MRI signals, with consequences on tractography performances and reliability? This communication aims to elaborate on these aspects, highlighting the importance of tracking and studying the developing connections with dedicated approaches.

摘要

在人类大脑中,白质发育是一个复杂且持久的过程,涉及微观和宏观结构机制的相互交织,如纤维生长、修剪和髓鞘形成。你知道吗?所有这些神经发育变化都会强烈影响磁共振成像(MRI)信号,进而影响纤维束成像的性能和可靠性。本交流旨在详细阐述这些方面,强调采用专门方法追踪和研究发育中连接的重要性。

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1
Small brains but big challenges: white matter tractography in early life samples.大脑虽小,但挑战巨大:早年样本中的白质纤维束成像
Brain Struct Funct. 2025 Apr 28;230(4):58. doi: 10.1007/s00429-025-02922-8.
2
Prevalence of white matter pathways coming into a single white matter voxel orientation: The bottleneck issue in tractography.单个体素内进入的白质通路的出现率:追踪中的瓶颈问题。
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Regional variation of white matter development in the cat brain revealed by ex vivo diffusion MR tractography.通过离体扩散磁共振纤维束成像揭示猫脑白质发育的区域差异。
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本文引用的文献

1
Human white matter myelinates faster in utero than ex utero.人类的脑白质在子宫内比在子宫外发育得更快。
Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2303491120. doi: 10.1073/pnas.2303491120. Epub 2023 Aug 7.
2
Concurrent mapping of brain ontogeny and phylogeny within a common space: Standardized tractography and applications.在共同空间中同时绘制大脑个体发育和系统发育图谱:标准化纤维束成像及其应用。
Sci Adv. 2022 Oct 21;8(42):eabq2022. doi: 10.1126/sciadv.abq2022. Epub 2022 Oct 19.
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Chemical and mechanical control of axon fasciculation and defasciculation.
轴突成束与解束的化学和机械控制
Semin Cell Dev Biol. 2023 May 15;140:72-81. doi: 10.1016/j.semcdb.2022.06.014. Epub 2022 Jul 6.
4
White matter myelination during early infancy is linked to spatial gradients and myelin content at birth.婴儿早期的白质髓鞘形成与出生时的空间梯度和髓鞘含量有关。
Nat Commun. 2022 Feb 22;13(1):997. doi: 10.1038/s41467-022-28326-4.
5
A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging.一种基于数据驱动的方法,用于优化多壳扩散 MRI 的编码,应用于新生儿成像。
NMR Biomed. 2020 Sep;33(9):e4348. doi: 10.1002/nbm.4348. Epub 2020 Jul 6.
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Neural histology and neurogenesis of the human fetal and infant brain.人类胎儿和婴儿大脑的神经组织学和神经发生。
Neuroimage. 2019 Mar;188:743-773. doi: 10.1016/j.neuroimage.2018.12.043. Epub 2018 Dec 27.
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A framework for multi-component analysis of diffusion MRI data over the neonatal period.新生儿期扩散 MRI 数据的多分量分析框架。
Neuroimage. 2019 Feb 1;186:321-337. doi: 10.1016/j.neuroimage.2018.10.060. Epub 2018 Nov 2.
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Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project.新生儿弥散 MRI 在人类连接组计划发展中的自动化处理流水线。
Neuroimage. 2019 Jan 15;185:750-763. doi: 10.1016/j.neuroimage.2018.05.064. Epub 2018 May 28.
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MRI and M/EEG studies of the White Matter Development in Human Fetuses and Infants: Review and Opinion.胎儿和婴儿白质发育的MRI与M/EEG研究:综述与观点
Brain Plast. 2016 Dec 21;2(1):49-69. doi: 10.3233/BPL-160031.
10
The emergence of functional architecture during early brain development.早期大脑发育过程中的功能架构的出现。
Neuroimage. 2017 Oct 15;160:2-14. doi: 10.1016/j.neuroimage.2017.01.047. Epub 2017 Jan 20.