Jahangiri Leila
School of Science and Technology, Nottingham Trent University, Clifton Site, Nottingham, NG11 8NS, UK.
Division of Cellular and Molecular Pathology, Department of Pathology, Addenbrookes Hospital, University of Cambridge, Cambridge, CB0 2QQ, UK.
Mol Biol Rep. 2025 Apr 28;52(1):435. doi: 10.1007/s11033-025-10548-6.
The trans-Golgi network is a major sorting organelle consisting of a tubular membrane originating from the trans-Golgi cisternae. Proteins and lipids synthesised in the endoplasmic reticulum are transported through the Golgi apparatus and sorted in the trans-Golgi network into pleomorphic transport carriers targeted for various destinations. These destinations include the apical and basolateral membranes, early and late, recycling endosomes, and secretory granules. The trans-Golgi network also accepts retrograde endosome traffic, contributing to the recycling of proteins and lipids, and, therefore, sits at the crossroads of secretory and endosomal systems. Cancer is a somatic evolutionary process that comprises the accumulation of mutations that contribute to tumourigenesis, growth, progression, immune evasion, and resistance to therapy. This study aims to catalogue how multiple components and players of the trans-Golgi network affect tumour progression. Further, the link between the tumour microenvironment, the trans-Golgi network, and tumour progression will be dissected. A more profound understanding of these mechanisms will inform better treatment options.
反式高尔基体网络是一种主要的分拣细胞器，由源自反式高尔基体潴泡的管状膜组成。在内质网中合成的蛋白质和脂质通过高尔基体运输，并在反式高尔基体网络中被分拣到靶向不同目的地的多形性运输载体中。这些目的地包括顶端和基底外侧膜、早期和晚期再循环内体以及分泌颗粒。反式高尔基体网络还接受逆行性内体运输，促进蛋白质和脂质的再循环，因此处于分泌系统和内体系统的交叉点。癌症是一个体细胞进化过程，包括导致肿瘤发生、生长、进展、免疫逃逸和治疗抗性的突变积累。本研究旨在编目反式高尔基体网络的多个组成部分和参与者如何影响肿瘤进展。此外，将剖析肿瘤微环境、反式高尔基体网络与肿瘤进展之间的联系。对这些机制更深入的理解将为更好的治疗选择提供依据。
