Abboud Fares, Alsiddig Hind, Haddad Sultaneh, Daradkeh Basil, Bayat Ghassan, Haneyah Farah
Damascus University, Faculty of Medicine, Damascus, Syrian Arab Republic.
Nile University, Faculty of Medicine, Khartoum, Sudan.
Medicine (Baltimore). 2025 Apr 25;104(17):e42019. doi: 10.1097/MD.0000000000042019.
Thyroid nodular goiter is a prevalent condition requiring imaging for diagnosis and management. Ultrasonography and thyroid scintigraphy are commonly used modalities, but their comparative diagnostic roles remain unclear. To compare ultrasonography and thyroid scintigraphy findings in nodular goiter patients, evaluate correlations between thyroid uptake and blood flow indices, and assess the role of imaging in determining thyroid and nodule size. A cross-sectional observational study conducted from January to November 2021 at the radiation and isotopes center Khartoum. The study included 100 adult patients (86% female, 14% male) with nodular goiter, aged 19 to 70 years (mean: 39.26 ± 14.19 years), randomly selected. Ultrasonography was performed using a high-frequency linear transducer (6-15 MHz) to evaluate thyroid and nodule size, echogenicity, texture, and blood flow indices (resistive index, PI, PSV). Scintigraphy utilized technetium-99m to classify thyroid gland uptake (high, normal, low). Data were analyzed using SPSS; P < .05 was considered significant. Demographics: most participants were aged 19 to 35 (46%) and married (76%). Isoechoic nodules were most common (68%), with 60% showing heterogeneous texture. High uptake was observed in 74% of patients, normal in 10%, and low in 16%. Significant differences were found across uptake categories for resistive index (P = .00), PI (P = .00), and PSV (P = .005). A moderate positive correlation (R² = 0.4075) existed between thyroid size and nodule size. Uptake did not significantly affect thyroid or nodule size. Ultrasonography provided detailed structural and vascular data, while scintigraphy evaluated gland-wide functional activity. Ultrasonography and scintigraphy complement each other in managing nodular goiter. Combining modalities enhances diagnostic accuracy and treatment planning.
甲状腺结节性甲状腺肿是一种常见疾病，诊断和管理需要影像学检查。超声检查和甲状腺闪烁扫描是常用的检查方法，但其比较诊断作用仍不明确。为比较结节性甲状腺肿患者的超声检查和甲状腺闪烁扫描结果，评估甲状腺摄取与血流指数之间的相关性，并评估影像学检查在确定甲状腺和结节大小方面的作用。2021年1月至11月在喀土穆辐射与同位素中心进行了一项横断面观察性研究。该研究纳入了100例年龄在19至70岁（平均：39.26±14.19岁）的成年结节性甲状腺肿患者（86%为女性，14%为男性），随机选取。使用高频线性探头（6-15MHz）进行超声检查，以评估甲状腺和结节的大小、回声、质地和血流指数（阻力指数、搏动指数、峰值流速）。闪烁扫描利用锝-99m对甲状腺摄取情况进行分类（高、正常、低）。使用SPSS对数据进行分析；P<0.05被认为具有统计学意义。人口统计学特征：大多数参与者年龄在19至35岁（46%）且已婚（76%）。等回声结节最为常见（68%），60%显示质地不均匀。74%的患者摄取高，10%正常，16%低。在不同摄取类别中，阻力指数（P=0.00）、搏动指数（P=0.00）和峰值流速（P=0.005）存在显著差异。甲状腺大小与结节大小之间存在中度正相关（R²=0.4075）。摄取情况对甲状腺或结节大小没有显著影响。超声检查提供了详细的结构和血管数据，而闪烁扫描评估了全腺的功能活性。超声检查和闪烁扫描在结节性甲状腺肿的管理中相互补充。联合使用这两种方法可提高诊断准确性和治疗规划水平。
