Thomson Pamela, Santibáñez Rodrigo, Garrido Daniel, Iturriaga María Paz, Flores Carla
Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
One Health Institute, Faculty of Life Sciences, Universidad Andrés Bello, Santiago, Chile.
Curr Microbiol. 2025 Apr 28;82(6):265. doi: 10.1007/s00284-025-04216-y.
Periodontal disease is a multifactorial condition commonly observed in domestic cats, characterized by inflammation and alveolar bone loss. This study aimed to elucidate the differences in the oral microbiome between healthy cats and those with periodontitis, focusing on microbial community structure and preliminary functionality. An observational case-control study was conducted involving 30 cats, divided equally into healthy and periodontitis groups. Gingival swabs were collected and analyzed using V3_V4 regions of the 16S rRNA sequencing. The results revealed that while the dominant phyla in both groups were Bacteroidota and Bacillota, cats with periodontitis exhibited decreased levels of Ochrobactrum, Odoribacter denticanis, Treponema denticola, Porphyromonas macacae, and Fretibacterium fastidiosum which are the characteristics of the periodontal oral microbiome. Predicted function indicated the enrichment of pathways related to the biosynthesis of fatty acids in periodontal disease, such as ubiquinol and mycolate production. These findings highlight significant microbial and functional shifts associated with feline periodontal disease, providing a basis for potential diagnostic and therapeutic strategies.
牙周病是一种在家猫中常见的多因素疾病，其特征为炎症和牙槽骨丧失。本研究旨在阐明健康猫与牙周炎猫口腔微生物群的差异，重点关注微生物群落结构和初步功能。进行了一项观察性病例对照研究，涉及30只猫，平均分为健康组和牙周炎组。采集牙龈拭子并使用16S rRNA测序的V3_V4区域进行分析。结果显示，虽然两组中的优势菌门均为拟杆菌门和芽孢杆菌门，但牙周炎猫的苍白杆菌属、龋齿气味杆菌、齿垢密螺旋体、猕猴卟啉单胞菌和苛求杆菌属水平降低，这些是牙周口腔微生物群的特征。预测功能表明牙周病中与脂肪酸生物合成相关的途径富集，如泛醇和霉菌酸的产生。这些发现突出了与猫牙周病相关的显著微生物和功能变化，为潜在的诊断和治疗策略提供了依据。
