Sheen I S, Liaw Y F, Tai D I, Chu C M
Gastroenterology. 1985 Oct;89(4):732-5. doi: 10.1016/0016-5085(85)90566-9.
To examine hepatic decompensation associated with acute exacerbation preceding hepatitis B e antigen clearance in chronic type B hepatitis, 376 patients with chronic hepatitis who were hepatitis B e antigen-positive were prospectively studied for up to 7 yr (mean 25 mo). Among the 165 patients who underwent hepatitis B e antigen clearance, 4 patients experienced hepatic decompensation and one of them eventually developed hepatic encephalopathy and died. The incidence of hepatic decompensation associated with hepatitis B e antigen clearance was 2.4%. We suggest that such an event in previously unrecognized chronic hepatitis B carriers could have been erroneously interpreted as acute or subacute hepatic failure, and that it might have been the result of a stronger enhancement of the host immune response.
为研究慢性乙型肝炎患者在乙肝e抗原清除前急性加重期相关的肝失代偿情况，对376例乙肝e抗原阳性的慢性肝炎患者进行了长达7年（平均25个月）的前瞻性研究。在165例实现乙肝e抗原清除的患者中，4例发生了肝失代偿，其中1例最终发展为肝性脑病并死亡。与乙肝e抗原清除相关的肝失代偿发生率为2.4%。我们认为，以前未被识别的慢性乙肝携带者出现的此类事件可能被错误地解释为急性或亚急性肝衰竭，这可能是宿主免疫反应增强更明显的结果。
