Cao Yan, Hu Bangqi, Zhou Wei, Liu Zhengyu, Pei Yanfang, Yu Jiang, Hu Conglong, Liu Xin, Han Xiaotong, Yan Xiquan, He Liudang, Ding Ning
Department of Emergency Medicine, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Sepsis Research Center of Hunan Provincial Geriatric Institute, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
BMC Infect Dis. 2025 Apr 28;25(1):618. doi: 10.1186/s12879-025-10979-3.
Escherichia coli (E.coli) is the leading pathogen for deaths associated with antimicrobial resistance, making it the most problematic bacteria for human infections. This study aimed to investigate the association between serum magnesium levels and clinical outcomes in patients with E.coli sepsis.
Data of E.coli septic patients were collected from the MIMIC-IV database. Patients were divided into three groups based on tertiles of serum magnesium levels. Three models were utilized, including the raw model (unadjusted), Model I (adjusted for age and gender), and Model II (adjusted for all potential confounding factors). Linear model and two-segment nonlinear model were established to examine the relationship between serum magnesium and 30-day, 60-day, and 90-day mortality rates. Kaplan-Meier survival curve analysis was performed to assess cumulative hazard of mortalities at 30-day, 60-day, 90-day based on tertiles of serum magnesium levels.
A total of 421 E.coli septic patients were included and classified into tertiles: Q1(< 1.6 mg/dL), Q2 (1.6-1.9 mg/dL), Q3(> 1.9 mg/dL). In the Model adjusting for all potential confounders, for every 1 mg/dL increase in serum magnesium, there was a significant increase in 30-day, 60-day, and 90-day mortality rates, with odds ratios of 4.01 (95% CI 1.22-13.19, P = 0.022), 4.81 (95% CI 1.59-14.53, P = 0.005), and 4.45 (95% CI 1.52-12.96, P = 0.006) respectively. And linear model is more suitable for describing the relationship between serum magnesium levels and clinical outcomes. Kaplan-Meier analysis revealed that the cumulative hazard of mortalities at 30-day, 60-day, 90-day increased with the prolongation of hospital stay, particularly in the group with the highest serum magnesium level.
Increased level of serum magnesium is significantly associated with increased risk of 30-day, 60-day and 90-day mortality in a population of septic patients with E.coli infection.
大肠杆菌是与抗菌药物耐药性相关死亡的主要病原体，使其成为人类感染中最具问题的细菌。本研究旨在调查大肠杆菌败血症患者血清镁水平与临床结局之间的关联。
从MIMIC-IV数据库收集大肠杆菌败血症患者的数据。根据血清镁水平的三分位数将患者分为三组。使用了三个模型，包括原始模型（未调整）、模型I（根据年龄和性别调整）和模型II（根据所有潜在混杂因素调整）。建立线性模型和两段式非线性模型来检验血清镁与30天、60天和90天死亡率之间的关系。进行Kaplan-Meier生存曲线分析，以评估基于血清镁水平三分位数的30天、60天、90天死亡率的累积风险。
共纳入421例大肠杆菌败血症患者，并分为三分位数：Q1（<1.6mg/dL）,Q2（1.6 - 1.9mg/dL）,Q3（>1.9mg/dL）。在调整所有潜在混杂因素的模型中，血清镁每升高1mg/dL，30天、60天和90天死亡率显著增加，比值比分别为4.01（95%CI 1.22 - 13.19，P = 0.022）、4.81（95%CI 1.59 - 14.53，P = 0.005）和4.45（95%CI 1.52 - 12.96，P = 0.006）。并且线性模型更适合描述血清镁水平与临床结局之间的关系。Kaplan-Meier分析显示，30天、60天、90天死亡率的累积风险随着住院时间的延长而增加，特别是在血清镁水平最高的组中。
在大肠杆菌感染的败血症患者群体中，血清镁水平升高与30天、60天和90天死亡风险增加显著相关。
