Wu Yi, Xu Yan, Bi Zhijun, Chen Jintian, Song Xin, Liao Shiyu, Jin Long, Bi Zhiguo, Han Yu, Liu Jianguo
The First Hospital of Jilin University, Changchun, Jilin Province, China.
Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, Jilin, China.
J Oral Rehabil. 2025 May;52(5):678-692. doi: 10.1111/joor.13916. Epub 2024 Dec 29.
Previous studies have linked sleep quality to temporomandibular joint disorders (TMD), suggesting a role for snoring in this association. However, the directionality of this relationship remains a subject of debate. This investigation aimed to elucidate the connections between snoring and TMD.
This research employed a two-sample Mendelian randomization (MR) approach, leveraging publicly available large-scale genome-wide association study (GWAS) data on snoring and TMD. We utilised a suite of analytical methods, including the inverse variance weighted (IVW) method, maximum likelihood estimation, adjusted profile score, weighted median, MR-Egger regression, and a series of sensitivity analyses, to rigorously assess the existence of relationships.
Our findings indicate that a greater genetic predisposition to snoring is significantly associated with a reduced risk of TMD (IVW method; odds ratio [OR] = 0.156, 95% confidence interval [CI] = 0.028-0.843, p = 0.0309). Conversely, the analysis did not support a potential influence of TMD on snoring susceptibility (IVW method; 95% CI = 0.990 to 1.002, p = 0.1926). Additionally, our sensitivity analyses did not reveal any significant pleiotropy that could bias these findings.
This MR study provides limited but novel genetic evidence supporting a potential causal link between snoring and a decreased risk of developing TMD. On the other hand, it does not substantiate an effect of TMD on the likelihood of snoring.
先前的研究已将睡眠质量与颞下颌关节紊乱症（TMD）联系起来，提示打鼾在这种关联中起作用。然而，这种关系的方向性仍是一个有争议的话题。本研究旨在阐明打鼾与TMD之间的联系。
本研究采用两样本孟德尔随机化（MR）方法，利用公开可用的关于打鼾和TMD的大规模全基因组关联研究（GWAS）数据。我们使用了一系列分析方法，包括逆方差加权（IVW）法、最大似然估计、调整后的轮廓评分、加权中位数、MR-Egger回归以及一系列敏感性分析，以严格评估关系的存在。
我们的研究结果表明，打鼾的遗传易感性增加与TMD风险降低显著相关（IVW法；优势比[OR]=0.156，95%置信区间[CI]=0.028 - 0.843，p = 0.0309）。相反，分析不支持TMD对打鼾易感性的潜在影响（IVW法；95%CI = 0.990至1.002，p = 0.1926）。此外，我们的敏感性分析未发现任何可能使这些结果产生偏差的显著多效性。
这项MR研究提供了有限但新颖的遗传证据，支持打鼾与TMD发病风险降低之间可能存在因果关系。另一方面，它并未证实TMD对打鼾可能性的影响。
