Cholidou Kyriaki, Anagnostopoulos Nektarios, Bartziokas Konstantinos, Vafeiadis Konstantinos, Bakakos Agamemnon, Vontetsianos Aggelos, Gogou Vasiliki, Sotiropoulou Zoi, Anagnostopoulou Christina, Papasarantou Anna, Steiropoulos Paschalis, Bakakos Petros, Papaioannou Andriana I
1 Respiratory Medicine Department, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Diseases Hospital, Athens, Greece.
Private Sector, Trikala, Greece.
Lung India. 2025 May 1;42(3):179-185. doi: 10.4103/lungindia.lungindia_422_24. Epub 2025 Apr 29.
Mean platelet volume (MPV) and red blood cll distribution width (RDW) have been assosiated with sleep apnea syndrome severity.
To investigate the correlation of mean platelet volume and red blood cell distribution width with obesity sleep apnoea syndrome (OSAS) severity.
Ninety patients underwent PSG. Patients with an apnoea-hypopnoea index (AHI) <5 were used as controls. Patients with AHI >5 were divided into mild: 5 ≤ AHI <15, moderate: 15≤ AHI <30 and severe OSAS: AHI ≥30. Patients >65 years, with body mass index (BMI) >40, central sleep apnoea syndrome, cardiovascular or other significant comorbidities were excluded. Blood sample collection occurred one day before polysomnography (PSG).
Sixty-four patients were included in our study. Fifty-seven (89.1%) had OSAS (16% mild, 25% moderate and 48.4% severe) while the remaining 7 (10.1%) were used as controls. MPV was similar among groups [8.1 (7.1, 9.2) vs 7.9 (6.8, 10.1) vs 8.5 (7.4, 9.1) vs 8.4 (7.6, 9.7), P = .930 for control, mild, moderate and severe OSAS, respectively]. RDW did not differ between OSAS patients and control [median (IQR) 14.4 (13.4, 15.3) vs 14.0 (13.5, 16.7), P = .950], while there was no significant difference among different stages of OSAS severity [14.0 (13.5, 16.7) vs 13.9 (11.4, 14.8) vs 14.4 (14.0, 15.3) vs 14.4 (13.3, 15.6), P = .517] for control, mild, moderate and severe OSAS, respectively.
OSAS patients have elevated levels of RDW and MPV compared to controls; however, there was no association between OSAS severity and MPV or RDW.
平均血小板体积（MPV）和红细胞分布宽度（RDW）与睡眠呼吸暂停综合征的严重程度相关。
探讨平均血小板体积和红细胞分布宽度与肥胖睡眠呼吸暂停综合征（OSAS）严重程度的相关性。
90例患者接受了多导睡眠图（PSG）检查。呼吸暂停低通气指数（AHI）<5的患者作为对照组。AHI>5的患者分为轻度：5≤AHI<15、中度：15≤AHI<30和重度OSAS：AHI≥30。排除年龄>65岁、体重指数（BMI）>40、中枢性睡眠呼吸暂停综合征、心血管或其他重大合并症的患者。在多导睡眠图（PSG）检查前一天采集血样。
64例患者纳入本研究。57例（89.1%）患有OSAS（16%为轻度，25%为中度，48.4%为重度），其余7例（10.1%）作为对照组。各组间MPV相似[对照组、轻度、中度和重度OSAS分别为8.1（7.1，9.2）对7.9（6.8，10.1）对8.5（7.4，9.1）对8.4（7.6，9.7），P=.930]。OSAS患者与对照组之间的RDW无差异[中位数（四分位间距）14.4（13.4，15.3）对14.0（13.5，16.7），P=.950]，而OSAS严重程度不同阶段之间无显著差异[对照组、轻度、中度和重度OSAS分别为14.0（13.5，16.7）对13.9（11.4,14.8）对14.4（14.0，15.3）对14.4（13.3，15.6），P=.517]。
与对照组相比，OSAS患者的RDW和MPV水平升高；然而，OSAS严重程度与MPV或RDW之间无关联。
