Shadrach Benhur Joel, Raju Lexmi Priya, Bibi Asma, Deokar Kunal, Gaikwad Priyanka, Doshi Jinish
Department of Pulmonary Medicine, Dr. Rela Institute and Medical Center, Chennai, Tamil Nadu, India.
Department of Pathology, Dr. Rela Institute and Medical Center, Chennai, Tamil Nadu, India.
Lung India. 2025 May 1;42(3):256-259. doi: 10.4103/lungindia.lungindia_557_24. Epub 2025 Apr 29.
Cervical lymphadenopathy can be due to numerous causes. The common causes include reactive and infections conditions in children and malignancy in the elderly. Kikuchi-Fujimoto disease (KFD) is a rare cause of cervical lymphadenopathy. As viral vaccines contain viral antigens, they can trigger the development of KFD. The human papillomavirus (HPV) vaccine can trigger KFD. It is important to elicit a history of prior vaccination to identify the trigger in patients with necrotising histiocytic lymphadenitis suspected of having KFD. We hereby report a case of a 16-year-old female who was diagnosed with HPV vaccine induced KFD. Ours is the first case to be reported from India. Histopathology revealed necrotising histiocytic lymphoid hyperplasia and the absence of neutrophils, eosinophils, plasma cells, vessel wall vasculitis, haematoxylin bodies, and Reed-Sternberg cells, and negative aerobic, MTB cultures, anti-nuclear antibodies, clinched the diagnosis of KFD.
颈部淋巴结病可由多种原因引起。常见原因包括儿童的反应性和感染性疾病以及老年人的恶性肿瘤。菊池-藤本病（KFD）是颈部淋巴结病的一种罕见病因。由于病毒疫苗含有病毒抗原，它们可引发KFD的发生。人乳头瘤病毒（HPV）疫苗可引发KFD。对于疑似患有KFD的坏死性组织细胞性淋巴结炎患者，了解既往疫苗接种史以确定触发因素很重要。我们在此报告一例16岁女性被诊断为HPV疫苗诱导的KFD。我们的病例是印度报告的首例。组织病理学显示坏死性组织细胞性淋巴样增生，且无中性粒细胞、嗜酸性粒细胞、浆细胞、血管壁血管炎、苏木精小体和里德-施特恩伯格细胞，需氧菌、结核分枝杆菌培养阴性，抗核抗体阴性，确诊为KFD。
