Ni Taolue, Ren Fang, Zhang Tianqi, Hua Dong, Chen Gang, Chen Hao
Department of Plastic Surgery and Wound Repair Surgery, Anqing Municipal Hospital, Anqing, China.
Department of Dermatology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
J Cosmet Dermatol. 2025 May;24(5):e70214. doi: 10.1111/jocd.70214.
Horizontal neck wrinkles are a prevalent sign of aging, with emerging research highlighting the effectiveness of treatments such as acupotomy subcision (AS) and hyaluronic acid (HA) injections in rejuvenating aged skin.
This study aims to evaluate and compare the efficacy of three distinct treatment modalities for neck wrinkles: AS, HA injections, and a combination of both. The primary objective is to determine which treatment approach offers the most effective and satisfactory outcomes in terms of wrinkle reduction and skin rejuvenation.
In this randomized clinical trial, 30 female participants with neck Allergan Transverse Neck Lines Scale (ATNLS) scores ranging from 3 to 4 were randomly allocated into three treatment groups: AS, HA, and AS+HA. Each participant received treatment once a month for 3 months, followed by clinical assessments at 1 month and 6 months posttreatment. The assessments included ATNLS scores, Global Aesthetic Improvement Scores (GAIS), and analysis of skin elasticity and collagen levels.
All treatment groups demonstrated improvements in ATNLS scores and GAIS after the final treatment. Notably, the AS+HA group showed a significantly higher number of participants reporting beneficial results at the 6-month follow-up. This group also exhibited a statistically significant increase in skin elasticity and collagen levels compared to the other groups.
The combined approach of HA and acupotomy subcision is effective in treating horizontal neck wrinkles, leading to significant improvements in skin elasticity and collagen levels. This study suggests that the synergistic effect of AS and HA may enhance the overall efficacy of treatments for reducing neck wrinkles, providing a promising option for patients seeking noninvasive neck rejuvenation.
颈部横纹是衰老的常见迹象，新出现的研究强调了诸如针刀分离术（AS）和透明质酸（HA）注射等治疗方法在使老化皮肤恢复活力方面的有效性。
本研究旨在评估和比较三种不同治疗方式对颈部皱纹的疗效：针刀分离术、透明质酸注射以及两者联合使用。主要目的是确定哪种治疗方法在减少皱纹和皮肤年轻化方面能提供最有效和令人满意的效果。
在这项随机临床试验中，30名颈部Allergan横向颈纹量表（ATNLS）评分在3至4分之间的女性参与者被随机分为三个治疗组：针刀分离术组、透明质酸注射组和针刀分离术+透明质酸联合组。每位参与者每月接受一次治疗，共治疗3个月，然后在治疗后1个月和6个月进行临床评估。评估包括ATNLS评分、整体美学改善评分（GAIS）以及皮肤弹性和胶原蛋白水平分析。
所有治疗组在最后一次治疗后ATNLS评分和GAIS均有改善。值得注意的是，针刀分离术+透明质酸联合组在6个月随访时有更多参与者报告有良好效果。与其他组相比，该组皮肤弹性和胶原蛋白水平也有统计学上的显著增加。
透明质酸和针刀分离术联合方法在治疗颈部横纹方面有效，可使皮肤弹性和胶原蛋白水平得到显著改善。本研究表明，针刀分离术和透明质酸的协同作用可能会增强减少颈部皱纹治疗的整体疗效，为寻求无创颈部年轻化的患者提供了一个有前景的选择。
