Oh Hyun Jun, Lee Jong-Ho, Kim Soung Min
Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
J Korean Assoc Oral Maxillofac Surg. 2025 Apr 30;51(2):123-125. doi: 10.5125/jkaoms.2025.51.2.123.
Growth differentiation factor 15 (GDF-15), a cytokine within the transforming growth factor-β superfamily, is involved in various malignancies, with implications in oral squamous cell carcinoma (OSCC). Elevated GDF-15 levels are correlated with unfavorable prognosis, tumor progression, and chemotherapy resistance, and the protein has been identified as a potential diagnostic and prognostic biomarker for OSCC. Personalized treatment strategies based on GDF-15 expression could improve treatment outcomes.
生长分化因子15（GDF-15）是转化生长因子-β超家族中的一种细胞因子，参与多种恶性肿瘤，与口腔鳞状细胞癌（OSCC）有关。GDF-15水平升高与不良预后、肿瘤进展和化疗耐药相关，该蛋白已被确定为OSCC的一种潜在诊断和预后生物标志物。基于GDF-15表达的个性化治疗策略可能会改善治疗效果。
