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禁食作为癌症治疗方法:肿瘤学中的神话还是突破?

Fasting as Cancer Treatment: Myth or Breakthrough in Oncology.

作者信息

Fatima Ghizal, Mehdi Abbas A, Fedacko Jan, Hadi Najah, Magomedova Aminat, Mehdi Ammar

机构信息

Department of Public Health, Era's Lucknow Medical College and Hospital, Era University, Lucknow, IND.

Department of Biochemistry, Era's Lucknow Medical College and Hospital, Era University, Lucknow, IND.

出版信息

Cureus. 2025 Mar 29;17(3):e81395. doi: 10.7759/cureus.81395. eCollection 2025 Mar.

Abstract

The concept of fasting as a potential cancer treatment has garnered increasing interest, particularly in light of emerging evidence linking dietary interventions to cancer progression and therapy outcomes. This article explores whether fasting, either intermittent or prolonged, can be a viable standalone treatment for cancer or if its therapeutic potential lies in its adjunctive role. Current research suggests that fasting induces a metabolic shift, which may inhibit cancer cell proliferation by depriving them of essential nutrients. Additionally, fasting has been shown to enhance the body's stress resistance, promote autophagy, and possibly make cancer cells more vulnerable to standard treatments such as chemotherapy and radiotherapy. However, the application of fasting as a sole treatment for cancer remains controversial and lacks substantial clinical validation. While animal models and in vitro studies indicate promising results, the translation to human trials is complex, with various types of cancer responding differently to dietary interventions. Moreover, concerns about malnutrition, loss of muscle mass, and the overall health of cancer patients undergoing fasting without supervision must be addressed. The paper critically examines the myth and reality surrounding fasting as a cancer treatment, reviewing key studies and clinical trials to provide a comprehensive understanding of its efficacy and safety. While fasting may hold promise as a supportive therapy, particularly in combination with traditional treatments, there is currently insufficient evidence to support its use as a primary treatment modality. Further research is needed to establish the parameters in which fasting might be beneficial, such as specific cancer types, patient populations, and optimal fasting regimens. Thus, while the idea of fasting as a cancer breakthrough is compelling, it remains a complementary approach rather than a standalone solution in oncology.

摘要

禁食作为一种潜在的癌症治疗方法的概念已引起越来越多的关注,尤其是鉴于新出现的证据将饮食干预与癌症进展和治疗结果联系起来。本文探讨了间歇性禁食或长期禁食是否可以作为一种可行的独立癌症治疗方法,或者其治疗潜力是否在于其辅助作用。目前的研究表明,禁食会引发代谢转变,这可能通过剥夺癌细胞必需的营养物质来抑制其增殖。此外,禁食已被证明可以增强身体的应激抵抗力、促进自噬,并可能使癌细胞更容易受到化疗和放疗等标准治疗的影响。然而,将禁食作为癌症的唯一治疗方法仍存在争议,并且缺乏大量的临床验证。虽然动物模型和体外研究显示出有希望的结果,但向人体试验的转化很复杂,不同类型的癌症对饮食干预的反应不同。此外,必须解决对营养不良、肌肉量减少以及在无监督情况下进行禁食的癌症患者整体健康状况的担忧。本文批判性地审视了围绕禁食作为癌症治疗方法的神话与现实,回顾了关键研究和临床试验,以全面了解其疗效和安全性。虽然禁食作为一种支持性疗法可能有前景,特别是与传统治疗方法联合使用时,但目前没有足够的证据支持将其用作主要治疗方式。需要进一步研究来确定禁食可能有益的参数,例如特定的癌症类型、患者群体和最佳禁食方案。因此,虽然禁食作为癌症突破的想法很有吸引力,但在肿瘤学中它仍然是一种辅助方法而不是独立的解决方案。

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