Kikomeko Joachim, Schutte Tim, van Velzen Merel J M, Seefat Rianne, van Laarhoven Hanneke W M
Department of Oncology, Amsterdam UMC location Vrije Universiteit Amsterdam, de Boelelaan, Amsterdam, 1117, the Netherlands.
Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands.
Ther Adv Med Oncol. 2023 Mar 22;15:17588359231161418. doi: 10.1177/17588359231161418. eCollection 2023.
Many patients with cancer search for and use alternative and complementary treatments, aiming to improve the effectiveness of their anticancer treatment and a reduction in treatment-associated side effects. Short-term fasting (STF) and fasting mimicking diets (FMDs) are among the most commonly used dietary interventions. In recent years, different trials have reported the promising results of dietary interventions in combination with chemotherapy, in terms of slowing down tumor growth and reduction in chemotherapy-related side effects. In this narrative review, we identify and describe the current evidence about feasibility and effects of STF and FMDs in cancer patients receiving chemotherapy. The studies that examined the effects of STF when combined with chemotherapy suggest potential benefits regarding reduction in side effects and improved quality of life. We also conclude with a list of well-designed studies that are still recruiting patients, examining the long-term effects of STF.
许多癌症患者寻求并使用替代疗法和补充疗法，旨在提高抗癌治疗的效果并减少治疗相关的副作用。短期禁食（STF）和模拟禁食饮食（FMD）是最常用的饮食干预措施。近年来，不同的试验报告了饮食干预与化疗联合使用在减缓肿瘤生长和减少化疗相关副作用方面的有前景的结果。在这篇叙述性综述中，我们识别并描述了关于短期禁食和模拟禁食饮食在接受化疗的癌症患者中的可行性和效果的现有证据。研究STF与化疗联合使用效果的研究表明，在减少副作用和改善生活质量方面有潜在益处。我们还列出了一系列仍在招募患者的精心设计的研究，这些研究正在考察短期禁食的长期效果。
