White Sarah E, Heine R Phillips, Widelock Talla M
Department of Obstetrics Gynecology, Section of Maternal Fetal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Antibiotics (Basel). 2025 Apr 7;14(4):387. doi: 10.3390/antibiotics14040387.
Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, remains the third leading cause of maternal mortality globally. Pregnancy-associated physiological adaptations predispose pregnant individuals to infection, impair maternal response to infection, affect antibiotic pharmacokinetics and metabolism, and complicate diagnosing infections and sepsis. Therefore, it is tantamount that clinicians readily recognize maternal sepsis and understand antibiotic regimens and treatment principles to avoid adverse maternal outcomes. In this article, we present an overview of the diagnosis and management of maternal sepsis and the physiological changes in pregnancy that alter antibiotic pharmacokinetics. Common microorganisms implicated in maternal sepsis are discussed with an emphasis on and Group A due to their prevalence and morbidity in the pregnant population. Lastly, we provide an overview of commonly used antibiotics and dosage recommendations in the treatment of maternal infection and sepsis.
脓毒症是由宿主对感染的反应失调引起的危及生命的器官功能障碍，仍是全球孕产妇死亡的第三大主要原因。与妊娠相关的生理适应性变化使孕妇易受感染，损害母体对感染的反应，影响抗生素的药代动力学和代谢，并使感染和脓毒症的诊断复杂化。因此，临床医生能够及时识别孕产妇脓毒症并了解抗生素治疗方案和治疗原则以避免不良的孕产妇结局至关重要。在本文中，我们概述了孕产妇脓毒症的诊断和管理以及妊娠期间改变抗生素药代动力学的生理变化。讨论了与孕产妇脓毒症相关的常见微生物，重点是[具体内容缺失]和A组[具体内容缺失]，因为它们在孕妇群体中的患病率和发病率较高。最后，我们概述了治疗孕产妇感染和脓毒症常用的抗生素及其剂量建议。
