Hites Maya
Clinic of Infectious Diseases, Cliniques Universitaires de Bruxelles (CUB)-Erasme Hospital, Brussels, Belgium.
Front Med (Lausanne). 2021 Apr 15;8:640740. doi: 10.3389/fmed.2021.640740. eCollection 2021.
Sepsis, a life-threatening organ dysfunction caused by a dysregulated response to infection is a major public health concern, as it is a leading cause of mortality and critical illness worldwide. Antibiotics are one of the cornerstones of the treatment of sepsis; administering appropriate antibiotics in a rapid fashion to obtain adequate drug concentrations at the site of the infection can improve survival of patients. Nevertheless, it is a challenge for clinicians to do so. Indeed, clinicians today are regularly confronted with infections due to very resistant pathogens, and standard dosage regimens of antibiotics often do not provide adequate antibiotic concentrations at the site of the infection. We provide a narrative minireview of different anti-infectious treatments currently available and suggestions on how to deliver optimized dosage regimens to septic patients. Particular emphasis will be made on newly available anti-infectious therapies.
脓毒症是一种因对感染的反应失调而导致的危及生命的器官功能障碍，是一个重大的公共卫生问题，因为它是全球范围内死亡和危重病的主要原因。抗生素是脓毒症治疗的基石之一；迅速给予适当的抗生素以在感染部位获得足够的药物浓度可提高患者的生存率。然而，对临床医生来说，这样做是一项挑战。事实上，如今临床医生经常面临由极具耐药性的病原体引起的感染，而抗生素的标准给药方案往往无法在感染部位提供足够的抗生素浓度。我们对目前可用的不同抗感染治疗方法进行了一篇叙述性的小型综述，并就如何为脓毒症患者提供优化的给药方案提出了建议。将特别强调新出现的抗感染疗法。
