Grossini Elena, Venkatesan Sakthipriyan, Ola Pour Mohammad Mostafa
Laboratory of Physiology, Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy.
Antioxidants (Basel). 2025 Mar 21;14(4):372. doi: 10.3390/antiox14040372.
Mitochondria are of great importance in cell biology since they are major sites of adenosine triphosphate (ATP) production and are widely involved in different cellular pathways involved in the response to stress. During ATP production, reactive oxygen species (ROS) can be produced. While a small amount of ROS may be important for the regulation of physiological processes, at elevated levels they can turn into harmful agents leading to cellular damage. From a pathological perspective, it could be particularly interesting to focus on mitochondrial function in endothelial cells since they may be involved in the development of aging and in the onset of different diseases, including renal, cardio-metabolic, liver and neurodegenerative ones. However, to date, there are no surveys which address the above issues. To fill this gap, it may be valuable to collect recent findings about the role of mitochondria in the regulation of endothelial function, not only to increase knowledge about it but also for clinical applications. Here, we overview the most recent knowledge about the above issues in the view of characterizing the role of mitochondria in endothelial cells as an innovative potential target for the prevention of aging, as well as the treatment of the above pathological conditions.
线粒体在细胞生物学中至关重要，因为它们是三磷酸腺苷（ATP）产生的主要场所，并广泛参与应对应激的不同细胞途径。在ATP产生过程中，会产生活性氧（ROS）。虽然少量的ROS可能对生理过程的调节很重要，但在高水平时它们会变成导致细胞损伤的有害物质。从病理学角度来看，关注内皮细胞中的线粒体功能可能特别有趣，因为它们可能参与衰老的发展以及包括肾脏、心血管代谢、肝脏和神经退行性疾病在内的不同疾病的发生。然而，迄今为止，尚无针对上述问题的调查。为了填补这一空白，收集有关线粒体在内皮功能调节中作用的最新发现可能很有价值，这不仅可以增加对此的了解，还可用于临床应用。在此，我们从将线粒体在内皮细胞中的作用表征为预防衰老以及治疗上述病理状况的创新潜在靶点的角度，概述有关上述问题的最新知识。
