Wang Xinyi, Liu Zhiyuan, Zhang Ling, Hu Guangyu, Tao Ling, Zhang Fuyang
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Life Med. 2024 Apr 26;3(2):lnae017. doi: 10.1093/lifemedi/lnae017. eCollection 2024 Apr.
Mitochondrial transplantation (MT) is a promising therapeutic strategy that involves introducing healthy mitochondria into damaged tissues to restore cellular function. This approach has shown promise in treating cardiac diseases, such as ischemia-reperfusion injury, myocardial infarction, and heart failure, where mitochondrial dysfunction plays a crucial role. Transplanting healthy mitochondria into affected cardiac tissue has resulted in improved cardiac function, reduced infract size, and enhanced cell survival in preclinical studies. Beyond cardiac applications, MT is also being explored for its potential to address various noncardiac diseases, including stroke, infertility, and genetic mitochondrial disorders. Ongoing research focused on refining techniques for mitochondrial isolation, preservation, and targeted delivery is bolstering the prospects of MT as a clinical therapy. As the scientific community gains a deeper understanding of mitochondrial dynamics and pathology, the development of MT as a clinical therapy holds significant promise. This review provides an overview of recent research on MT and discusses the methodologies involved, including sources, isolation, delivery, internalization, and distribution of mitochondria. Additionally, it explores the effects of MT and potential mechanisms in cardiac diseases, as well as non-cardiac diseases. Future prospects for MT are also discussed.
线粒体移植（MT）是一种很有前景的治疗策略，它涉及将健康的线粒体引入受损组织以恢复细胞功能。这种方法在治疗心脏病方面已显示出前景，如缺血再灌注损伤、心肌梗死和心力衰竭，其中线粒体功能障碍起着关键作用。在临床前研究中，将健康的线粒体移植到受影响的心脏组织中已导致心脏功能改善、梗死面积减小和细胞存活率提高。除了心脏应用外，MT还因其解决各种非心脏疾病的潜力而受到探索，包括中风、不孕症和遗传性线粒体疾病。正在进行的专注于改进线粒体分离、保存和靶向递送技术的研究正在增强MT作为临床治疗方法的前景。随着科学界对线粒体动力学和病理学有更深入的了解，MT作为一种临床治疗方法的发展具有重大前景。本综述概述了MT的最新研究，并讨论了所涉及的方法，包括线粒体的来源、分离、递送、内化和分布。此外，还探讨了MT在心脏病以及非心脏疾病中的作用和潜在机制。还讨论了MT的未来前景。
