Potter B J, Chapman R W, Nunes R M, Sorrentino D, Sherlock S
Hepatology. 1985 Sep-Oct;5(5):714-21. doi: 10.1002/hep.1840050503.
The metabolism of transferrin was studied using purified 125I-labeled transferrin in 11 alcoholic patients; six with fatty liver and five with cirrhosis. Six healthy subjects whose alcohol intake was les than 40 gm daily were studied as a control group. There were no significant differences in the mean fractional catabolic rate and plasma volume in the alcoholic groups when compared with control subjects. A significantly decreased mean serum transferrin concentration was found in the alcoholic cirrhotic patients (1.8 +/- 0.3 gm per liter vs. 2.9 +/- 0.2; p less than 0.01), resulting from diminished total body synthesis (0.9 +/- 0.2 mg per kg per hr vs. 1.8 +/- 0.2; p less than 0.01). In contrast, in the patients with alcoholic fatty liver, the mean total body transferrin synthesis (2.4 +/- 0.3 mg per kg per hr) was significantly increased when compared with controls (p less than 0.05). For all the alcoholic patients, the serum transferrin correlated with transferrin synthesis (r = + 0.70; p less than 0.01) but the serum iron did not. These results suggest that, in alcoholic cirrhosis, transferrin synthesis is decreased, probably reflecting diminished synthetic capacity by the liver. In contrast, in patients with alcoholic fatty liver, transferrin turnover is accelerated.
使用纯化的125I标记转铁蛋白对11例酒精性肝病患者的转铁蛋白代谢进行了研究，其中6例为脂肪肝患者，5例为肝硬化患者。选取6名每日酒精摄入量低于40克的健康受试者作为对照组。与对照组相比，酒精性肝病组的平均分解代谢率和血浆量无显著差异。酒精性肝硬化患者的平均血清转铁蛋白浓度显著降低（1.8±0.3克/升对2.9±0.2；p<0.01），这是由于全身合成减少（0.9±0.2毫克/千克/小时对1.8±0.2；p<0.01）。相比之下，酒精性脂肪肝患者的全身转铁蛋白平均合成量（2.4±0.3毫克/千克/小时）与对照组相比显著增加（p<0.05）。对于所有酒精性肝病患者，血清转铁蛋白与转铁蛋白合成相关（r = + 0.70；p<0.01），但血清铁则不然。这些结果表明，在酒精性肝硬化中，转铁蛋白合成减少，这可能反映了肝脏合成能力的下降。相比之下，酒精性脂肪肝患者的转铁蛋白周转加快。
